Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial
Article first published online: 10 OCT 2006
Alimentary Pharmacology & Therapeutics
Volume 24, Issue 10, pages 1461–1468, November 2006
How to Cite
LIONETTI, E., MINIELLO, V. L., CASTELLANETA, S. P., MAGISTÁ, A. M., DE CANIO, A., MAUROGIOVANNI, G., IERARDI, E., CAVALLO, L. and FRANCAVILLA, R. (2006), Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial. Alimentary Pharmacology & Therapeutics, 24: 1461–1468. doi: 10.1111/j.1365-2036.2006.03145.x
- Issue published online: 10 OCT 2006
- Article first published online: 10 OCT 2006
- Publication data Submitted 4 July 2006 First decision 8 July 2006 Resubmitted 29 August 2006 Accepted 5 September 2006
Helicobacter pylori eradication fails in about 25–30% of children, particularly because of the occurrence of resistance to antibiotics and side-effects.
To determine whether adding the Lactobacillus reuteri to an anti-H. pylori regimen could help to prevent or minimize the gastrointestinal side-effects burden in children.
Forty H. pylori-positive children (21 males; median age: 12.3 years) were consecutively treated with 10-day sequential therapy [omeprazole + amoxycillin for 5 days, and omeprazole + clarithromycin + tinidazole for other 5 days] and blindly randomized to receive either L. reuteri ATCC 55730 (108 CFU) or placebo. All children completed the Gastrointestinal Symptom Rating Scale (GSRS) at entry, during and after treatment. H. pylori status was assessed after 8 weeks by 13C-urea breath test.
Overall, in all probiotic supplemented children when compared with those receiving placebo there was a significant reduction of GSRS score during eradication therapy (4.1 ± 2 vs. 6.2 ± 3; P < 0.01) and at the end of follow-up (3.2 ± 2 vs. 5.8 ± 3.4; P < 0.009). Overall, children receiving L. reuteri report less symptoms than those receiving placebo.
L. reuteri is capable of reducing frequency and intensity of antibiotic-associated side-effects during eradication therapy for H. pylori.