Consequences of frequent nocturnal gastro-oesophageal reflux disease among employed adults: symptom severity, quality of life and work productivity
Version of Record online: 9 JAN 2007
Alimentary Pharmacology & Therapeutics
Volume 25, Issue 4, pages 487–500, February 2007
How to Cite
DUBOIS, R. W., AGUILAR, D., FASS, R., ORR, W. C., ELFANT, A. B., DEAN, B. B., HARPER, A. S., YU, H.-T., MELMED, G. Y., LYNN, R., SINGH, A. and TEDESCHI, M. (2007), Consequences of frequent nocturnal gastro-oesophageal reflux disease among employed adults: symptom severity, quality of life and work productivity. Alimentary Pharmacology & Therapeutics, 25: 487–500. doi: 10.1111/j.1365-2036.2006.03189.x
- Issue online: 9 JAN 2007
- Version of Record online: 9 JAN 2007
- Publication data Submitted 17 April 2006 First decision 11 May 2006 Resubmitted 1 November 2006 Accepted 2 November 2006
Effects of frequent nocturnal symptoms of gastro-oesophageal reflux disease (GERD-FNS) on health-related quality of life (HRQOL) and work productivity are not well documented.
To assess symptom severity, production loss, and HRQOL among employed adults with and without GERD-FNS.
Using several validated outcome measures in a web survey design, GERD was pre-specified as GERD Symptom and Medication Questionnaire score >9, and ≥1 episode of heartburn or acid regurgitation during the preceding week. GERD-FNS patients were those reporting ≥2 symptom-nights during the previous week; their outcomes were compared with those of patients having minimal or no nocturnal symptoms (GERD-NNS) and vs. non-GERD controls.
Data were collected from 1002 GERD patients (476 GERD-FNS, 526 GERD-NNS) and 513 controls. Severe symptoms were more common, sleep abnormalities were more frequent (P < 0.0001) and SF-36 scores lower (P < 0.05, all scores) among GERD-FNS patients vs. GERD-NNS patients. GERD-related work loss was greater among those with GERD-FNS vs. GERD-NNS (P < 0.0001). Work loss and functional limitations were more pronounced when comparing GERD-FNS cases vs. non-GERD controls.
Employed adults with frequent nocturnal GERD report more severe symptoms, and are associated with impaired sleep, HRQOL and work productivity compared with controls and patients with minimal or no nocturnal symptoms.