Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children
Article first published online: 19 DEC 2006
Alimentary Pharmacology & Therapeutics
Volume 25, Issue 3, pages 257–264, February 2007
How to Cite
SZAJEWSKA, H., SKÓRKA, A. and DYLAG, M. (2007), Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children. Alimentary Pharmacology & Therapeutics, 25: 257–264. doi: 10.1111/j.1365-2036.2006.03202.x
- Issue published online: 8 JAN 2007
- Article first published online: 19 DEC 2006
- Publication data Submitted 19 October 2006 First decision 7 November 2006 Resubmitted 8 November 2006 Accepted 8 November 2006
Vol. 29, Issue 7, 800, Article first published online: 5 MAR 2009
Saccharomyces boulardii is a non-pathogenic probiotic yeast considered useful against enteropathogens.
To assess the effectiveness of S. boulardii in treating acute infectious diarrhoea in children.
The following electronic databases were searched through August 2006 for studies relevant to acute infectious diarrhoea and S. boulardii: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additional references were obtained from reviewed articles. Only randomized-controlled trials were included.
Five randomized-controlled trials (619 participants) met the inclusion criteria. Combined data from four randomized-controlled trials showed that S. boulardii significantly reduced the duration of diarrhoea compared with control. The pooled weighted mean difference was −1.1 days (95% CI: −1.3 to −0.8) with a fixed model and remained significant in a random effect model. Saccharomyces boulardii significantly reduced the risk of diarrhoea on days 3, 6 and 7. Also the risk of diarrhoea lasting >7 days was significantly reduced in the S. boulardii group vs. control group (1 RCT, n = 88, RR 0.25, 95% CI: 0.08–0.83; NNT 5, 95% CI: 3–20).
There exists a moderate clinical benefit of S. boulardii therapy in otherwise healthy infants and children with acute gastroenteritis, mainly a shorter duration of diarrhoea. However, these results should be interpreted with caution due to methodological limitations of the included studies.