Systematic review: oral bowel preparation for colonoscopy
Article first published online: 7 DEC 2006
Alimentary Pharmacology & Therapeutics
Volume 25, Issue 4, pages 373–384, February 2007
How to Cite
BELSEY, J., EPSTEIN, O. and HERESBACH, D. (2007), Systematic review: oral bowel preparation for colonoscopy. Alimentary Pharmacology & Therapeutics, 25: 373–384. doi: 10.1111/j.1365-2036.2006.03212.x
- Issue published online: 7 DEC 2006
- Article first published online: 7 DEC 2006
- Publication data Submitted 31 October 2006 First decision 6 November 2006 Resubmitted 23 November 2006 Accepted 23 November 2006
There are many published trials of colon cleansing regimens for colonoscopy but no clear consensus regarding relative performance.
To identify high quality controlled trials comparing two or more bowel preparation regimens and to compare efficacy and tolerability.
A comprehensive systematic review was carried out to identify candidate studies. Quality appraisal was carried out on all identified studies. Results were meta-analysed where possible and qualitatively compared if not.
Eighty-two studies qualified for analysis. Polyethylene glycol and sodium phosphate were the most frequently investigated preparations. There was no significant efficacy difference between the two, but sodium phosphate was better tolerated. Sodium picosulphate/magnesium citrate, a commonly prescribed preparation, was investigated in four studies, with no clear benefit over other regimens demonstrated. Safety was not recognized as a problem in the randomized controlled trials. Published case series demonstrate that sodium phosphate is associated with the highest risk of clinically significant electrolyte disturbances.
Shortcomings in study design limit the value of many of the studies. Based on these results, no single bowel preparation emerges as consistently superior. New preparations are required that combine better efficacy and tolerability, in addition to rigorous new validated study designs, allowing unequivocal comparisons to be made.