Persisting symptoms and decreased health-related quality-of-life in a cross-sectional study of treated achalasia patients
Version of Record online: 2 JUL 2007
Alimentary Pharmacology & Therapeutics
Volume 26, Issue 6, pages 899–904, September 2007
How to Cite
FRANKHUISEN, R., VAN HERWAARDEN, M. A., HEIJKOOP, R., SMOUT, A. J. P. M., BARON, A., VERMEIJDEN, J. R., GOOSZEN, H. G. and SAMSOM, M. (2007), Persisting symptoms and decreased health-related quality-of-life in a cross-sectional study of treated achalasia patients. Alimentary Pharmacology & Therapeutics, 26: 899–904. doi: 10.1111/j.1365-2036.2007.03423.x
- Issue online: 2 JUL 2007
- Version of Record online: 2 JUL 2007
- Publication data Submitted 28 May 2007 First decision 15 June 2007 Resubmitted 25 June 2007 Accepted 26 June 2007
Little is known about symptom characteristics of treated achalasia patients and their effect on health-related quality-of-life (HRQoL).
To examine clinical remission, achalasia-associated symptoms and HRQoL in treated achalasia patients.
The Eckardt clinical symptom score, RAND-36 and a disease-specific HRQoL questionnaire were sent to 171 treated achalasia patients.
76.6% of the patients returned their questionnaire. 44.9% of them were not in symptomatic remission. Prevalence of frequent dysphagia (at least daily) and chest pain (at least weekly) was 46% and 38%, respectively. Achalasia patients had lower general HRQoL scores than control subjects (all RAND-36 subscales, except health change; P ≤ 0.002). Patients with frequent symptoms of chest pain and dysphagia showed lower HRQoL than patients with less frequent symptoms on three RAND-36 subscales (pain, social functioning and general health perceptions; P < 0.003). Patients in clinical remission showed higher HRQoL than patients who were not, however HRQoL in the ‘remission group’ remained significantly impaired as compared to controls (all RAND-36 subscales except emotional role limitations and mental health; P < 0.001).
Many achalasia patients remain severely symptomatic after treatment and have decreased HRQoL. Frequent symptoms are associated with lower HRQoL. Patients in clinical remission show substantially improved, but not restored HRQoL.