Long-term survival of patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoinfusion
Version of Record online: 2 JUL 2007
Alimentary Pharmacology & Therapeutics
Volume 26, Issue 6, pages 839–846, September 2007
How to Cite
HA, B. Y., AHMED, A., SZE, D. Y., RAZAVI, M. K., SIMPSON, N., KEEFFE, E. B. and NGUYEN, M. H. (2007), Long-term survival of patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoinfusion. Alimentary Pharmacology & Therapeutics, 26: 839–846. doi: 10.1111/j.1365-2036.2007.03424.x
- Issue online: 2 JUL 2007
- Version of Record online: 2 JUL 2007
- Publication data Submitted 02 June 2007 First decision 24 June 2007 Resubmitted 26 June 2007 Accepted 26 June 2007
Transcatheter arterial chemoembolization (TACE) has become one of the most common treatments for unresectable hepatocellular carcinoma. Published studies of TACE report a 5–16% risk of serious complications. Compared with TACE, transcatheter arterial chemoinfusion (TACI) may have similar efficacy and fewer side effects.
To examine the clinical outcomes of TACI.
We performed a retrospective cohort study of 345 consecutive TACI cases in 165 patients performed at a single United States medical center between 1998 and 2002. Primary outcomes were tumour response and survival rates.
Only seven patients were hospitalized for more than 24 h after the procedure, and only three patients had worsening of liver function within 30 days of TACI. Survival was significantly poorer for patients with tumour-node-metastasis (TNM) IV compared to those with TNM I–III and also for patients with Child’s class B/C vs. A. Following adjustment for age, gender, ethnicity and aetiology of liver diseases, independent predictors of poor survival were Child’s class B/C [Hazard Ratio (HR) = 1.69, P = 0.024] and TNM IV staging (HR = 1.63, P = 0.014).
TACI appears to be safe and effective for unresectable hepatocellular carcinoma with TNM stage I–III; randomized controlled trials are needed to compare TACI to TACE.