• 1
    Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet 2007; 369: 162740.
  • 2
    Massey D, Parkes M. Common pathways in Crohn’s disease and other inflammatory diseases revealed by genomics. Gut 2007; 56: 148992.
  • 3
    Hugot J, Chamaillard M, Zouali H, et al. Association of NOD2 leucine rich repeat variants with susceptibility to Crohn’s disease. Nature 2001; 411: 599603.
  • 4
    Ogura Y, Bonen D, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 2001; 411: 6036.
  • 5
    Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: 14613.
  • 6
    Dubinsky MC, Wang D, Picornell Y, et al. IL-23 receptor (IL-23R) gene protects against pediatric Crohn’s disease. Inflamm Bowel Dis 2007; 13: 5115.
  • 7
    Rioux JD, Xavier RJ, Taylor KD, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007; 39: 596604.
  • 8
    Libioulle C, Louis E, Hansoul S, et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 2007; 3: e58.
  • 9
    Tremelling M, Cummings F, Fisher SA, et al. IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology 2007; 132: 165764.
  • 10
    Welcome Trust Case Control Consortium. Genome-wide associations study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 66178.
  • 11
    Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007; 39: 20711.
  • 12
    Prescott NJ, Fisher SA, Franke A, et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn’s disease and is independent of CARD15 and IBD5. Gastroenterology 2007; 132: 166571.
  • 13
    Monsuur AJ, De Bakker PIW, Alizadeh BZ, et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet 2005; 12: 13414.
  • 14
    Van Belzen MJ, Meijer JW, Sandkuijl LA, et al. A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology 2003; 125: 103241.
  • 15
    Van Heel DA, Fisher SA, Kirby A, Daly MJ, Rioux JD, Lewis CM. Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet 2004; 13: 76370.
  • 16
    Rioux JD, Silverberg MS, Daly MJ, et al. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet 2000; 66: 186370.
  • 17
    Post PL, Tyska MJ, O’Connell CB, Johung K, Hayward A, Mooseker MS. Myosin-IXb is a single-headed and processive motor. J Biol Chem 2002; 277: 1167983.
  • 18
    Bruewer M, Hopkins AM, Hobert ME, Nusrat A, Madara JL. RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am J Physiol Cell Physiol 2004; 287: C32735.
  • 19
    Ueda H, Howson JM, Esposito L, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423: 50611.
  • 20
    Begovich AB, Carlton VE, Honigberg LA, et al. A missense single nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004; 75: 3307.
  • 21
    Bottini N, Musumeci L, Alonso A, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 2004; 36: 3378.
  • 22
    Amundsen SS, Vatn M, IBSEN Study Group, Wijmenga C, Sollid LM, Lie BA. Association analysis of MYO9B gene polymorphisms and inflammatory bowel disease in a Norwegian cohort. Tissue Antigens 2006; 68: 24952.
  • 23
    Van Bodegraven AA, Curley CR, Hunt KA, Monsuur AJ, Linskens RK, Onnie CM. Genetic variation in myosin IXB is associated with ulcerative colitis. Gastroenterology 2006; 131: 176874.
  • 24
    Nunez C, Oliver J, Mendoza JL, et al. MYO9B polymorphisms in patients with inflammatory bowel disease. Gut 2007; 56: 13212.
  • 25
    Podolski DK. Inflammatory bowel disease. N Engl J Med 2002; 347: 41729.
  • 26
    Best WR, Becktel JM, Singleton JW, Kern F. Development of a Crohn’s disease activity index. Gastroenterology 1976; 70: 43944.
  • 27
    D’Inca R, Annese V, Di Leo V, et al. Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn’s disease. Aliment Pharmacol Ther 2006; 23: 145561.
  • 28
    Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19 (Suppl. A): 536.
  • 29
    Becker KG. The common genetic hypothesis of autoimmune/inflammatory disease. Curr Opin Allergy Clin Immunol 2001; 1: 399405.
  • 30
    Sánchez E, Alizadeh BZ, Valdigem G, et al. Links MYO9B gene polymorphisms are associated with autoimmune diseases in Spanish population. Hum Immunol 2007; 68: 6105.
  • 31
    Altshuler D, Daly M. Guilt beyond a reasonable doubt. Nat Genet 2007; 39: 8135.
  • 32
    Post PL, Tyska MJ, O’Connell CB, Johung K, Hayward A, Mooseker MSJ. Myosin-IXb is a single-headed and processive motor. Biol Chem 2002; 277: 1167983.
  • 33
    Inoue A, Saito J, Ikebe R, Ikebe M. Myosin IXb is a single-headed minus-end-directed processive motor. Nat Cell Biol 2002; 4: 3026.
  • 34
    Wirth JA, Jensen KA, Post PL, Bement WM, Mooseker MS. Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. J Cell Sci 1996; 109: 65361.
  • 35
    Schmidt A, Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 2002; 16: 1587609.
  • 36
    Van den Boom F, Dussmann H, Uhlenbrock K, Abouhamed M, Bahler M. The myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization. Mol Biol Cell 2007; 18: 150718.
  • 37
    Yu Y, Sitaraman S, Gewirtz AT. Intestinal epithelial cell regulation of mucosal inflammation. Immunol Res 2004; 29: 5568.
  • 38
    Peeters M, Greypens B, Claus D, et al. Clustering of increased small intestinal permeability in families with Crohn’s disease. Gastroenterology 1997; 113: 8027.
  • 39
    McDonald TT, Monteleone G. Immunity, inflammation, and allergy in the gut. Science 2005; 307: 19205.
  • 40
    Yang A, Chen Y, Scherl E, Neugut AI, Bhagat G, Green PH. Inflammatory bowel disease in patients with celiac disease. Inflamm Bowel Dis 2005; 11: 52832.
  • 41
    Buhner S, Bunung S, Genschel J, et al. Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? Gut 2006; 55: 32447.