Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine
Article first published online: 6 NOV 2007
DOI: 10.1111/j.1365-2036.2007.03567.x
Additional Information
How to Cite
MANOLAKOPOULOS, S., BETHANIS, S., KOUTSOUNAS, S., GOULIS, J., VLACHOGIANNAKOS, J., CHRISTIAS, E., SAVERIADIS, A., PAVLIDIS, C., TRIANTOS, C., CHRISTIDOU, A., PAPATHEODORIDIS, G., KARAMANOLIS, D. and TZOURMAKLIOTIS, D. (2008), Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Alimentary Pharmacology & Therapeutics, 27: 266–273. doi: 10.1111/j.1365-2036.2007.03567.x
Publication History
- Issue published online: 6 NOV 2007
- Article first published online: 6 NOV 2007
- Publication data Submitted 2 August 2007First decision 3 September 2007 Resubmitted 1 October 2007 Accepted 30 October 2007
Vol. 27, Issue 6, 528–529, Article first published online: 20 FEB 2008
References
- 1, . Chronic hepatitis B. Hepatology 2007; 45: 507–39.
- 2, , . World-wide epidemiology of HBeg-negative chronic hepatitis B and associated precore and core promoter variants. J Viral Hepat 2002; 9: 52–61.
- 3, . Epidemiology of precore mutants of hepatitis B in the United Kingdom. J Med Virol 2000; 62: 463–70.Direct Link:
- 4. Hepatitis B e antigen negative chronic hepatitis B: from clinical recognition to pathogenesis and treatment. Viral Hepat Rev 1995; 1: 7–36.
- 5, . Hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2001; 34: 617–24.Direct Link:
- 6, . Current management of chronic hepatitis B. Aliment Pharmacol Ther 2004; 19: 25–37.
- 7, , . Customizing the management of chronic hepatitis B virus infection. Semin Liver Dis 2007; 27 (Suppl. 1): 9–17.
- 8, , , et al. Clinical course of lamivudine monotherapy in patients with decompensated cirrhosis due to HBeAg-negative chronic hepatitis B. Am J Gastroenterol 2004; 99: 57–63.Direct Link:
- 9, , , et al. Outcome of patients with HBeAg-negative chronic hepatitis B under nucleos(t)ide analogues maintenance therapy starting with lamivudine. Hepatology 2005; 42: 121–9.
- 10, , , et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years. Gastroenterology 2006; 131: 1743–51.
- 11, , , et al. Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation. J Hepatol 2005; 43: 937–43.
- 12, , , et al. Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation patients. Hepatology 2003; 38: 1419–27.
- 13, , , et al. Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus. Gastroenterology 2004; 126: 81–90.
- 14, , , et al. Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B. Gastroenterology 2004; 126: 91–101.
- 15, , , et al. Evaluation of a new assay for HBV DNA quantitation in patients with chronic hepatitis B. Clin Diagn Virol 1998; 9: 37–43.
- 16, , , et al. Lamivudine monotherapy in HBeAg-negative chronic hepatitis B: prediction of response-breakthrough and long-term clinical outcome. Aliment Pharmacol Ther 2006; 23: 787–95.
- 17, , , et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696–9.
- 18, , , , . Course of virologic breakthroughs under long-term lamivudine in HBeAg-negative precore mutant HBV liver disease. Hepatology 2002; 36: 219–26.Direct Link:
- 19, , , . Adding-on versus switching to adefovir therapy in lamivudine resistant HBeAg-negative chronic hepatitis B. Hepatology 2007; 45: 307–13.
- 20, , , et al. Adefovir and lamivudine combination therapy is superior to adefovir monotherapy for lamivudine-resistant patients with HBeAg-negative chronic hepatitis B. Hepatology 2006; 44: 693A–4A.
- 21, , , et al. Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy. Hepatology 2006; 43: 1385–91.
- 22, , , , , . Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine. Hepatology 2006; 42: 1414–9.
- 23, , , et al. Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase. Gastroenterology 2003; 125: 292–7.
- 24, , , et al. Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. J Hepatol 2003; 39: 1085–9.
- 25, , , et al. Incidence and predictors of emergence of adefovir resistant HBV during four years of adefovir dipivoxil therapy for patients with chronic hepatitis B (abstract). J Hepatol 2005; 42: 17.

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