Adipokines and cytokines in non-alcoholic fatty liver disease
Article first published online: 10 DEC 2007
Alimentary Pharmacology & Therapeutics
Volume 27, Issue 5, pages 412–421, March 2008
How to Cite
JARRAR, M. H., BARANOVA, A., COLLANTES, R., RANARD, B., STEPANOVA, M., BENNETT, C., FANG, Y., ELARINY, H., GOODMAN, Z., CHANDHOKE, V. and YOUNOSSI, Z. M. (2008), Adipokines and cytokines in non-alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics, 27: 412–421. doi: 10.1111/j.1365-2036.2007.03586.x
- Issue published online: 10 DEC 2007
- Article first published online: 10 DEC 2007
- Publication data Submitted 8 November 2007 First decision 26 November 2007 Resubmitted 3 December 2007 Accepted 3 December 2007 Epub OnlineAccepted 10 December 2007
Background Several adipocytokines have been implicated in the pathogenesis non-alcoholic fatty liver disease (NAFLD).
Aim To assess adipocytokines in NAFLD patients and controls.
Methods A total of 95 patients (26 non-alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese controls and 12 non-obese controls) were included. Fasting serum insulin, glucose, visfatin, resistin, adiponectin, tumour necrosis factor-α (TNF-α), interleukin-8 (IL-8) and IL-6 were determined. Univariate and multivariate analyses were used to compare groups and determine associations.
Results Serum TNF-α and IL-8 were higher in NAFLD patients when compared with both obese and non-obese controls. Analysis involving all patients revealed a significant correlation between serum TNF-α and IL-8 (P < 6.319e−08), and between IL-6 and IL-8 (P < 5.271e−15). Homeostatic model assessment scores negatively correlated with adiponectin in NAFLD (P < 0.0032). Serum visfatin was higher in all three obese groups than in non-obese controls (P < 0.02, P < 0.002 and P < 0.008). Visfatin in NASH patients was lower than SS and obese controls. Although TNF-α was associated with NAFLD (P < 0.02), it was interdependent on visfatin. In comparison to SS, four factors were independently associated with NASH: age, alanine aminotransferase, IL-8 and adiponectin (P < 0.05). Multivariate analysis indicated that TNF-α was the only independent predictor of fibrosis in NASH (P < 0.0004).
Conclusion These findings support a complex interaction between adipocytokines and the pathogenesis of NAFLD.