Low body mass not vitamin D receptor polymorphisms predict osteoporosis in patients with inflammatory bowel disease
Article first published online: 10 JAN 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 27, Issue 7, pages 588–596, April 2008
How to Cite
NOBLE, C. L., MCCULLOUGH, J., HO, W., LEES, C. W., NIMMO, E., DRUMMOND, H., BEAR, S., HANNAN, J., MILLAR, C., RALSTON, S. H. and SATSANGI, J. (2008), Low body mass not vitamin D receptor polymorphisms predict osteoporosis in patients with inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 27: 588–596. doi: 10.1111/j.1365-2036.2008.03599.x
- Issue published online: 10 JAN 2008
- Article first published online: 10 JAN 2008
- Publication data Submitted 5 November 2007 First decision 2 December 2007 Resubmitted 20 December 2007 Accepted 21 December 2007 Epub OnlineAccepted 10 January 2008
Background Osteoporosis is a recognized complication of inflammatory bowel disease (IBD).
Aim To investigate the role of environmental factors and vitamin D receptor (VDR) variants on the prevalence of osteoporosis.
Methods DEXA scans and case note review were performed on 440 IBD patients from 1997 to 2006. All the IBD patients and 240 healthy controls were genotyped for VDR variants Taq-1 and Apa-1 using PCR-RFLP.
Results Osteoporosis and osteopenia rates were 15% and 18% for IBD, 16% and 18% for Crohn’s disease (CD) and 13% and 19% for ulcerative colitis, respectively. On univariate analysis of the CD patients, low body mass index (BMI, <18.5) and smoking status (P = 0.008 and 0.005 respectively) were associated with osteoporosis and osteopenia. Low BMI was also associated with osteoporosis on multivariate analysis in CD (P = 0.021, OR 5.83, CI 1.31–25.94). No difference was observed between Taq-1 and Apa-1 VDR polymorphisms in IBD, CD, ulcerative colitis and healthy controls. However, CD males were more likely to carry the variant Taq-1 polymorphism than healthy controls males (P = 0.0018, OR 1.94, CI 1.28–2.92) and female CD patients (P = 0.0061, OR 1.60, CI 1.17–2.44).
Conclusions In this well-phenotyped cohort of IBD patients, a relatively low prevalence of osteoporosis was observed. Low BMI was the only independent risk factor identified to be associated with osteoporosis.