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Appendix S1. List of excluded publications and reasons for exclusion

Figure S1. Trial sequential analyses of 15 trials on glucocorticosteroids vs. placebo or no intervention for patients with alcoholic hepatitis. The heterogeneity-corrected information size (HIS) based on a relative risk of 0.31 in low-bias risk trials, mortality in the control group of 53.6%, alpha = 5%, and beta = 20% is 95 patients (vertical dotted line). The dotted lines are trial sequential monitoring boundaries calculated accordingly. The heterogeneity-corrected information size (HIS) using alpha = 1% and beta = 20% is 142 patients (vertical etched line). The etched lines are trial sequential monitoring boundaries calculated accordingly. The green lines are z score of −1.96 and 1.96, equal to two-sided P = 0.05. X-axis: the information size, i.e. the number of patients randomized (blue line) and Y-axis is z score

Figure S2. Trial sequential analyses of six trials on glucocorticosteroids vs. placebo or no intervention for patients with alcoholic hepatitis including patients with Maddrey’s score of at least 32 or hepatic encephalopathy. The heterogeneity-corrected information size (HIS) based on a relative risk of 0.80, mortality in the control group of 50%, alpha = 5%, and beta = 20% is 1627 patients (vertical dotted line). The dotted lines are trial sequential monitoring boundaries calculated accordingly (merges with the dotted lines below). The heterogeneity-corrected information size (HIS) using alpha = 1% and beta = 20% is 2420 patients (vertical etched line). The etched lines are trial sequential monitoring boundaries calculated accordingly. The green lines are z score of −1.96 and 1.96, equal to two-sided P = 0.05. X-axis: the information size, i.e. the number of patients randomized (blue line) and Y-axis is z score

Figure S3. Funnel plot of mortality in 15 trials on glucocorticosteroids vs. placebo or no intervention for patients with alcoholic hepatitis. The X-axis depicts the relative risks (RR) observed in the individual trials and the Y-axis depicts the standard error (S.E.) to the log RR. Due to lack of events in one trial only 14 trials provided data

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FilenameFormatSizeDescription
APT_3685_sm_Excluded_trials_Appendix_APT.doc30KSupporting info item
APT_3685_sm_Figure S1.eps1610KSupporting info item
APT_3685_sm_Figure S2.eps1606KSupporting info item
APT_3685_sm_Figure S3.eps400KSupporting info item
APT_3685_sm_legend_Figs1-3.doc28KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.