Clinical trial: oral feeding with a soft diet compared with clear liquid diet as initial meal in mild acute pancreatitis
Article first published online: 4 JUL 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 28, Issue 6, pages 777–781, September 2008
How to Cite
SATHIARAJ, E., MURTHY, S., MANSARD, M. J., RAO, G. V., MAHUKAR, S. and REDDY, D. N. (2008), Clinical trial: oral feeding with a soft diet compared with clear liquid diet as initial meal in mild acute pancreatitis. Alimentary Pharmacology & Therapeutics, 28: 777–781. doi: 10.1111/j.1365-2036.2008.03794.x
- Issue published online: 20 AUG 2008
- Article first published online: 4 JUL 2008
- Publication data Submitted 29 May 2008 First decision 6 June 2008 Resubmission 13 June 2008 Accepted 1 July 2008 Epub Accepted Article 4 July 2008
Background In mild acute pancreatitis, traditional treatment has been initial fasting and oral refeeding with clear liquids to prevent adverse gastrointestinal events such as pain. The diet is gradually progressed to soft solids and hospital discharge is planned based on patients’ tolerance to a solid diet.
Aim To determine the length of hospitalization and tolerance to oral refeeding when initiated on a soft diet as compared to a clear liquid diet.
Methods One hundred and one patients with mild acute pancreatitis were randomized to receive either a clear liquid diet or soft diet when oral feeding was initiated. Frequency of pain, total and postrefeeding length of hospitalization, and dietary intake were monitored. Hospital discharge was decided by the medical team without input from the study coordinators.
Results A statistically significant decrease in the length of hospitalization (total and postrefeeding) of a median of 2 days was seen in patients receiving a soft diet (P < 0.001). No significant difference in the need for cessation of diet because of pain was observed between the two groups. Patients initiated on a soft diet consumed significantly more calories and fats on study day 1 (P < 0.001).
Conclusion Oral refeeding with a soft diet in patients with mild acute pancreatitis can be considered safe and can result in shorter length of hospitalization.