Clinical trial: gluten microchallenge with wheat-based starch hydrolysates in coeliac disease patients – a randomized, double-blind, placebo-controlled study to evaluate safety
Article first published online: 16 AUG 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 28, Issue 10, pages 1240–1248, November 2008
How to Cite
KAUKINEN, K., SALMI, T., COLLIN, P., HUHTALA, H., KÄRJÄ-LAHDENSUU, T. and MÄKI, M. (2008), Clinical trial: gluten microchallenge with wheat-based starch hydrolysates in coeliac disease patients – a randomized, double-blind, placebo-controlled study to evaluate safety. Alimentary Pharmacology & Therapeutics, 28: 1240–1248. doi: 10.1111/j.1365-2036.2008.03832.x
- Issue published online: 16 OCT 2008
- Article first published online: 16 AUG 2008
- Publication data Submitted 11 June 2008 First decision 4 July 2008 Resubmitted 6 August 2008 Accepted 13 August 2008 Epub Accepted Article 16 August 2008
Background Wheat-based starch hydrolysates such as glucose syrups, dextrose and maltodextrins are found in more than 50% of European processed food. These products contain low amounts of residual gluten and it has been questioned whether they are safe for coeliac disease patients.
Aim To investigate whether coeliac disease patients can safely consume wheat-based starch hydrolysate products.
Methods This randomized, double-blind, placebo-controlled, prospective follow-up study involved 90 coeliac disease patients in remission randomized to consume glucose syrups, maltodextrins or placebo for 24 weeks. Small bowel mucosal morphology and inflammation, symptoms, coeliac serology and malabsorption laboratory data were evaluated at baseline and at the end of the study.
Results Daily ingestion of wheat-based starch hydrolysates, glucose syrups and maltodextrins, had no deleterious effect on small-bowel mucosal villous architecture or inflammation in coeliac disease patients when compared to the placebo group. Neither were there any significant differences in gastrointestinal symptoms, serology or malabsorption parameters after 24 weeks.
Conclusions Wheat-based starch hydrolysates, glucose syrups and maltodextrins did not have harmful effect on coeliac disease patients. Coeliac patients can thus safely continue to consume these products.