Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings
Article first published online: 26 AUG 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 28, Issue 10, pages 1221–1229, November 2008
How to Cite
SIPPONEN, T., KÄRKKÄINEN, P., SAVILAHTI, E., KOLHO, K.-L., NUUTINEN, H., TURUNEN, U. and FÄRKKILÄ, M. (2008), Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings. Alimentary Pharmacology & Therapeutics, 28: 1221–1229. doi: 10.1111/j.1365-2036.2008.03835.x
- Issue published online: 16 OCT 2008
- Article first published online: 26 AUG 2008
- Publication data Submitted 27 May 2008 First decision 26 June 2008 Resubmitted 15 August 2008 Accepted 15 August 2008 Epub Accepted Article 26 August 2008
Background Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn’s disease (SES-CD) and with histological findings are as yet limited.
Aim To study the correlation of faecal calprotectin and lactoferrin with SES-CD and histology.
Methods During 87 consecutive ileocolonoscopies, SES-CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured.
Results In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES-CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES-CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448).
Conclusion In ileocolonic and colonic disease, endoscopic score SES-CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal-marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.