Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet
Article first published online: 20 JAN 2009
© 2009 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 29, Issue 8, pages 811–816, April 2009
How to Cite
HALLERT, C., SVENSSON, M., THOLSTRUP, J. and HULTBERG, B. (2009), Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet. Alimentary Pharmacology & Therapeutics, 29: 811–816. doi: 10.1111/j.1365-2036.2009.03945.x
- Issue published online: 19 MAR 2009
- Article first published online: 20 JAN 2009
- Publication data Submitted 30 January 2008 First decision 6 February 2008 Resubmitted 14 November 2008, 11 December 2008, 14 January 2009 Accepted 14 January 2009 Epub Accepted Article 20 January 2009
Background Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status.
Aim To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease.
Methods In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45–64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status.
Results Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 μmol/L (7.4–23.0), significantly higher than in matched population controls [10.2 μmol/L (6.7–22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being.
Conclusions Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.