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Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk

  1. L. YIN,
  2. N. GRANDI,
  3. E. RAUM,
  4. U. HAUG,
  5. V. ARNDT,
  6. H. BRENNER

Article first published online: 15 APR 2009

DOI: 10.1111/j.1365-2036.2009.04022.x

Issue

Alimentary Pharmacology & Therapeutics

Alimentary Pharmacology & Therapeutics

Volume 30, Issue 2, pages 113–125, July 2009

Additional Information

How to Cite

YIN, L., GRANDI, N., RAUM, E., HAUG, U., ARNDT, V. and BRENNER, H. (2009), Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Alimentary Pharmacology & Therapeutics, 30: 113–125. doi: 10.1111/j.1365-2036.2009.04022.x

Author Information

  1. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse, Heidelberg, Germany

*Dr H. Brenner, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D-69115 Heidelberg, Germany. E-mail: h.brenner@dkfz.de

Publication History

  1. Issue published online: 26 JUN 2009
  2. Article first published online: 15 APR 2009
  3. Publication data Submitted 12 February 2009 First decision 16 March 2009 Resubmitted 8 April 2009 Accepted 14 April 2009 Epub Accepted Article 15 April 2009

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Summary

Background  In 1980, Garland hypothesized that lower levels of vitamin D resulting from much weaker UV-B radiation at higher latitudes may account for the striking geographical pattern of cancer mortality. Further research has been conducted over the past 20 years.

Aim  To perform a systematic review and meta-analysis of longitudinal studies on the association between serum 25 hydroxyvitamin D (25(OH)D) and the risk of colorectal cancer (CRC).

Methods  Relevant studies published until September 2008 were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. Due to the heterogeneity of studies in categorizing serum vitamin D levels, all results were recalculated for an increase of serum 25(OH)D by 20 ng/mL. Summary odds ratios (ORs) were calculated using meta-analysis methods.

Results  Overall, eight original articles reporting on the association between serum 25(OH) D and CRC risk were included. In meta-analyses, summary ORs (95% confidence intervals) for the incidence of CRC, colon cancer and rectal cancer associated with an increase of 25(OH)D by 20 ng/mL were 0.57 (0.43–0.76), 0.78 (0.54–1.13) and 0.41 (0.11–1.49). No indication for publication bias was found.

Conclusions  Our results support suggestions that serum 25(OH)D is inversely related to CRC risk.

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