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Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii
Article first published online: 23 JUL 2009
DOI: 10.1111/j.1365-2036.2009.04102.x
© 2009 Blackwell Publishing Ltd
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How to Cite
POTHOULAKIS, C. (2009), Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii. Alimentary Pharmacology & Therapeutics, 30: 826–833. doi: 10.1111/j.1365-2036.2009.04102.x
Publication History
- Issue published online: 16 SEP 2009
- Article first published online: 23 JUL 2009
- Publication data Submitted 10 April 2009 First decision 28 April 2009 Resubmitted 17 July 2009 Accepted 20 July 2009 Epub Accepted Article 23 July 2009
References
- 1, , . NF-kappaB in inflammatory bowel disease. J Intern Med 2008; 263: 591–6.
- 2, . Mechanisms of tissue damage in inflammatory bowel disease. Curr Opin Gastroenterol 2001; 17: 307–12.
- 3. Nuclear factor-kappa B activation and innate immune response in microbial pathogen infection. Biochem Pharmacol 2000; 60: 1109–14.
- 4, . NF-kappa B: ten years after. Cell 1996; 87: 13–20.
- 5. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649–83.
- 6, . The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004; 25: 280–8.
- 7, . The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection. Am J Physiol Cell Physiol 2000; 278: C451–62.
- 8, . NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseases. Inflamm Bowel Dis 2000; 6: 206–13.
- 9, . Cytokine and anti-cytokine therapies for inflammatory bowel disease. Curr Pharm Des 2003; 9: 1107–13.
- 10, . Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997; 9: 180–6.
- 11, , , et al. p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. J Biol Chem 2000; 275: 23814–24.
- 12, . Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. J Biol Chem 1999; 274: 8355–8.
- 13, , . Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immun 1993; 61: 4569–74.
- 14, , . Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestals. Infect Immun 2001; 69: 3315–22.
- 15, , , , , . Enterohemorrhagic Escherichia coli infection induces interleukin-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-kappaB and AP-1 in T84 cells. Infect Immun 2002; 70: 2304–10.
- 16, , , , . Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8. Cell Microbiol 2002; 4: 635–48.
- 17, , , , , . Shiga toxin produced by enterohemorrhagic Escherichia coli inhibits PI3K/NF-kappaB signaling pathway in globotriaosylceramide-3-negative human intestinal epithelial cells. J Immunol 2007; 178: 8168–74.
- 18, , , , , . Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli-induced signaling pathways in T84 cells. Infect Immun 2003; 71: 766–73.
- 19, , , et al. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun 2006; 343: 69–76.
- 20, . Diarrheagenic Escherichia coli. Clin Microbiol Rev 1998; 11: 142–201.
- 21. Early enterocyte responses to enteropathogenic E. coli. J Pediatr Gastroenterol Nutr 2005; 40(Suppl 1): S32.
- 22. Adherence of Escherichia coli serogroup O 157 and the Salmonella typhimurium mutant DT 104 to the surface of Saccharomyces boulardii. Mycoses 1999; 42: 261–4.
- 23, , , , . Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells. Infect Immun 2000; 68: 5998–6004.
- 24, , , , , . Enteropathogenic Escherichia coli decreases the transepithelial electrical resistance of polarized epithelial monolayers. Infect Immun 1993; 61: 2755–62.
- 25, , , , , . Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res 2006; 60: 24–9.
- 26, . Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins. Am J Physiol Gastrointest Liver Physiol 2001; 280: G178–83.
- 27. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006; 101: 812–22.
- 28, , , et al. Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. Gastroenterology 1993; 104: 1108–15.
- 29, , , . Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infect Immun 1996; 64: 5225–32.
- 30, , , , . Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun 1999; 67: 302–7.
- 31, , , et al. Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice. Infect Immun 2001; 69: 2762–5.
- 32, , , . Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 2000; 342: 390–7.
- 33, , . Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced up-regulation and secretion of IL-8 from human monocytes. J Immunol 1999; 163: 5183–91.
- 34, , , et al. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology 2002; 122: 1048–57.
- 35, , , et al. A p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest 2000; 105: 1147–56.
- 36, , , et al. Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology 2005; 129: 1875–88.
- 37, , , et al. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem 2006; 281: 24449–54.
- 38, , , . Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells. J Immunol 2000; 165: 903–14.
- 39, . IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis. J Immunol 2004; 173: 4197–206.
- 40, , , , . Effect of Saccharomyces boulardii against experimental oral infection with Salmonella typhimurium and Shigella flexneri in conventional and gnotobiotic mice. J Appl Bacteriol 1996; 81: 251–6.
- 41, , , . Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. Am J Physiol Gastrointest Liver Physiol 2008; 294: G599–609.
- 42, . Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn’s disease with special respect to chronic diarrhea--a pilot study. Z Gastroenterol 1993; 31: 129–34.
- 43, , , . Saccharomyces boulardii in maintenance treatment of Crohn’s disease. Dig Dis Sci 2000; 45: 1462–4.
- 44, , . A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 2003; 15: 697–8.
- 45, , , , . The Effect of Saccharomyces boulardii on Human Colon Cells and Inflammation in Rats with Trinitrobenzene Sulfonic Acid-Induced Colitis. Dig Dis Sci 2008; 54: 255–63.
- 46, , , et al. PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut 2006; 55: 1341–9.
- 47, , , et al. [Saccharomyces boulardii activates expression of peroxisome proliferator-activated receptor-gamma in HT-29 cells]. Korean J Gastroenterol 2005; 45: 328–34.
- 48, . Saccharomyces boulardii decreases inflammation and intestinal colonization by Candida albicans in a mouse model of chemically-induced colitis. Med Mycol 2007; 45: 691–700.
- 49, . Immunopathogenesis of inflammatory bowel disease. World J Gastroenterol 2008; 14: 390–400.
- 50, , , , . Citrobacter rodentium of mice and man. Cell Microbiol 2005; 7: 1697–706.
- 51, . Commensal host-bacterial relationships in the gut. Science 2001; 292: 1115–8.
- 52. Animal models of inflammatory bowel disease: lessons from enteric infections. Ann N Y Acad Sci 2006; 1072: 28–38.
- 53, , , et al. Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors. Am J Physiol Gastrointest Liver Physiol 2008; 294: G295–306.
- 54, , , , , . Intimin and the host cell – is it bound to end in Tir(s)? Trends Microbiol 2001; 9: 214–8.
- 55, , , et al. Saccharomyces boulardii inhibits inflammatory bowel disease by trapping T cells in mesenteric lymph nodes. Gastroenterology 2006; 131: 1812–25.
- 56. Probiotics in inflammatory bowel disease: yet another mechanism of action? Gastroenterology 2006; 131: 2009–12.
- 57. Understanding why probiotic therapies can be effective in treating IBD. J Clin Gastroenterol 2008; 42(Suppl 3 Pt 1): S111–5.

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