This uncommissioned systematic review was subject to full peer-review.
Systematic review: impact of constipation on quality of life in adults and children
Article first published online: 20 FEB 2010
© 2010 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 31, Issue 9, pages 938–949, May 2010
How to Cite
BELSEY, J., GREENFIELD, S., CANDY, D. and GERAINT, M. (2010), Systematic review: impact of constipation on quality of life in adults and children. Alimentary Pharmacology & Therapeutics, 31: 938–949. doi: 10.1111/j.1365-2036.2010.04273.x
- Issue published online: 5 APR 2010
- Article first published online: 20 FEB 2010
- Publication data Submitted 27 July 2009 First decision 7 September 2009 Resubmitted 9 February 2010 Accepted 18 February 2010 Epub Accepted Article 20 February 2010
Aliment Pharmacol Ther 31, 938–949
Background Comparison of quality of life (QoL) across disease areas requires the use of appropriate tools. Although many studies have investigated QoL in constipation, most used disease-specific tools that are inappropriate for cross-comparisons.
Aims To identify studies of QoL in constipation and to compare these results with other chronic conditions.
Methods A comprehensive literature search identified studies in constipation that used a generic QoL tool. Results were statistically pooled where possible and compared with published results using the same tools in other chronic conditions.
Results A total of 13 qualifying studies were identified, 10 in adults and three in children. Results from eight studies using the SF-36/12 tools were pooled; the remaining five were narratively reported. Mental and physical components of QoL scores were consistently impaired in both adult and child populations, with the greatest impact being seen in secondary care studies. Mental health effects predominated over physical domains. The magnitude of impact was comparable with that seen in patients with allergies, musculoskeletal conditions and inflammatory bowel disease.
Conclusions The impact of constipation on QoL is significant and comparable with other common chronic conditions. Improving management may prove to be an effective way of improving QoL for a substantial number of patients.