The quality of sleep in patients with coeliac disease
Article first published online: 16 AUG 2010
© 2010 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 32, Issue 8, pages 1031–1036, October 2010
How to Cite
Zingone, F., Siniscalchi, M., Capone, P., Tortora, R., Andreozzi, P., Capone, E. and Ciacci, C. (2010), The quality of sleep in patients with coeliac disease. Alimentary Pharmacology & Therapeutics, 32: 1031–1036. doi: 10.1111/j.1365-2036.2010.04432.x
- Issue published online: 26 SEP 2010
- Article first published online: 16 AUG 2010
- Publication data Submitted 15 June 2010 First decision 30 June 2010 Resubmitted 22 July 2010 Accepted 25 July 2010
Aliment Pharmacol Ther 2010; 32: 1031–1036
Background Coeliac disease is a chronic disease with a various clinical presentation, including anxiety and depression.
Aim To investigate the quality of sleep in coeliac disease.
Methods The participants were coeliacs at diagnosis; coeliacs on a gluten-free diet at follow-up and healthy volunteers. Participants completed the Pittsburgh Sleep Quality Index (PSQI), SF36, Zung and Fatigue scales and State-Trait Anxiety Inventory (STAI).
Results The PSQI score was higher in coeliacs at diagnosis and in a gluten-free diet than in healthy volunteers (P < 0.001). A gluten-free diet did not improve the PSQI score (P = 0.245) in coeliac disease. The other test scores were similar between coeliacs at diagnosis and those on a gluten-free diet, whereas significant differences were found between coeliacs and volunteers. PSQI score was inversely associated with the quality of the physical (r = −0.327, P = 0.002) and mental (r = −0.455, P < 0.001) component scores. The sleep quality scores were related to depression (r = 0.633, P < 0.001), fatigue (r = 0.377, P < 0.001), state anxiety (r = 0.484, P < 0.001) and trait anxiety (r = 0.467, P < 0.001).
Conclusions Sleep disorders are common in coeliac disease not only at diagnosis but also during treatment with a gluten-free diet. Sleep disorders are related to depression, anxiety and fatigue, and inversely related to quality of life scale scores.