Appropriateness of therapy for fistulizing Crohn’s disease: findings from a national inflammatory bowel disease cohort
Article first published online: 18 AUG 2010
© 2010 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 32, Issue 8, pages 1007–1016, October 2010
How to Cite
Pittet, V., Juillerat, P., Michetti, P., Vader, J.-P., Burnand, B., Rogler, G., Beglinger, C., Seibold, F., Mottet, C., Felley, C., Gonvers, J.-J., Froehlich, F. and The Swiss IBD Cohort Study Group (2010), Appropriateness of therapy for fistulizing Crohn’s disease: findings from a national inflammatory bowel disease cohort. Alimentary Pharmacology & Therapeutics, 32: 1007–1016. doi: 10.1111/j.1365-2036.2010.04434.x
- Issue published online: 26 SEP 2010
- Article first published online: 18 AUG 2010
- Publication data Submitted 17 March 2010 First decision 20 April 2010 Resubmitted 24 June 2010 Accepted 25 July 2010
Aliment Pharmacol Ther 2010; 32: 1007–1016
Background About 30–50% of patients with Crohn’s disease (CD) develop fistulae, implying significant disease burden and complicated clinical management.
Aim To assess appropriate use of therapy for fistulizing CD patients enrolled in the Swiss Inflammatory Bowel Disease Cohort using criteria developed by the European Panel on the Appropriateness of Crohn’s disease Therapy.
Methods Specific questionnaires were used to gather information on disease and its management. We assessed appropriateness of therapy at enrolment for adult CD patients with one or several fistulae.
Results Two hundred and eighty-eight CD patients had fistulizing disease, of which 80% had complex fistulae and 32% currently had active draining fistulae. Mean age (s.d.) at diagnosis was 27 years (11), 51% males. Of the patients, 78% were judged as having globally an appropriate therapy, which was more often given for complex fistulae (87%) than for simple fistulae (67%). Antibiotics, azathioprine/MP, methotrexate and conservative surgery were almost always appropriate. Anti-tumor necrosis factor α was considered globally appropriate (91%), although most often with an uncertain indication. The 5ASA compounds, steroids and aggressive surgery were most often inappropriate (84%, 58% and 86% respectively).
Conclusions Formal appropriateness criteria for CD therapy were applied to a national cohort of IBD patients. For more than three-quarters of the patients with fistulizing CD, therapy was globally appropriate.