Risk of colorectal adenomas in patients with coeliac disease
Article first published online: 17 AUG 2010
© 2010 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 32, Issue 8, pages 1037–1043, October 2010
How to Cite
Lebwohl, B., Stavsky, E., Neugut, A. I. and Green, P. H. R. (2010), Risk of colorectal adenomas in patients with coeliac disease. Alimentary Pharmacology & Therapeutics, 32: 1037–1043. doi: 10.1111/j.1365-2036.2010.04440.x
- Issue published online: 26 SEP 2010
- Article first published online: 17 AUG 2010
- Publication data Submitted 21 May 2010 First decision 29 June 2010 Resubmitted 6 July 2010 Accepted 1 August 2010
Aliment Pharmacol Ther 2010; 32: 1037–1043
Background Coeliac disease is associated with an increased risk of lymphoma and small bowel malignancy, but most studies have found no increased risk of colorectal cancer.
Aim To compare the prevalence of colorectal adenomas in coeliac disease patients with that in non-coeliac disease controls.
Methods We identified all coeliac disease patients who underwent colonoscopy at our institution during a 44-month period. We matched each patient with non-coeliac disease controls by age, gender and endoscopist. We compared the adenoma prevalence between these groups, and used multivariate analysis to assess the independent association of coeliac disease with adenomas.
Results We identified 180 patients with coeliac disease and 346 controls. At least one adenoma was present in 13% of coeliac disease patients and 17% of controls (P = 0.20). On multivariate analysis, age (OR per year 1.04, 95% CI 1.02–1.07) and male gender (OR 2.33, 95% CI 1.36–3.98) were associated with adenomas, while the relationship between coeliac disease and adenomas remained null (OR 0.75, 95% CI 0.41–1.34).
Conclusions Coeliac disease is not associated with an increased risk of colorectal neoplasia. The lack of increased risk of colorectal cancer observed in population studies is related to a true average risk of colorectal neoplasia, rather than artifactually reflecting increased colonoscopy and associated polypectomies in the coeliac population.