As part of AP&T’s peer-review process, a technical check of this meta-analysis was performed by Dr. P. Collins.
Meta-analysis: the association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux
Article first published online: 23 SEP 2010
Published 2010. This article is a US Government work and is in the public domain in the USA
Alimentary Pharmacology & Therapeutics
Volume 32, Issue 10, pages 1222–1227, November 2010
How to Cite
Rubenstein, J. H. and Taylor, J. B. (2010), Meta-analysis: the association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux. Alimentary Pharmacology & Therapeutics, 32: 1222–1227. doi: 10.1111/j.1365-2036.2010.04471.x
- Issue published online: 19 OCT 2010
- Article first published online: 23 SEP 2010
- Publication data Submitted 9 July 2010 First decision 4 August 2010 Resubmitted 3 September 2010 Accepted 5 September 2010 EV Pub Online 23 September 2010
Aliment Pharmacol Ther 2010; 32: 1222–1227
Background Endoscopic screening has been proposed for patients with symptoms of gastro-oesophageal reflux disease (GERD) in the hope of reducing mortality from oesophageal adenocarcinoma. Assessing the net benefits of such a strategy requires a precise understanding of the cancer risk in the screened population.
Aim To estimate precisely the association between symptoms of GERD and oesophageal adenocarcinoma.
Methods Systematic review and meta-analysis of population-based studies with strict ascertainment of exposure and outcomes.
Results Five eligible studies were identified. At least weekly symptoms of GERD increased the odds of oesophageal adenocarcinoma fivefold (odds ratio = 4.92; 95% confidence interval = 3.90, 6.22), and daily symptoms increased the odds sevenfold (random effects summary odds ratio = 7.40, 95% confidence interval = 4.94, 11.1), each compared with individuals without symptoms or less frequent symptoms. Duration of symptoms was also associated with oesophageal adenocarcinoma, but with very heterogeneous results, and unclear thresholds.
Conclusions Frequent GERD symptoms are strongly associated with oesophageal adenocarcinoma. These results should be useful in developing epidemiological models of the development of oesophageal adenocarcinoma, and in models of interventions aimed at reducing mortality from this cancer.