Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors
Article first published online: 19 OCT 2010
© 2010 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 33, Issue 1, pages 77–88, January 2011
How to Cite
Valkhoff, V. E., ‘t Jong, G. W., Van Soest, E. M., Kuipers, E. J. and Sturkenboom, M. C. J. M. (2011), Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors. Alimentary Pharmacology & Therapeutics, 33: 77–88. doi: 10.1111/j.1365-2036.2010.04485.x
- Issue published online: 5 DEC 2010
- Article first published online: 19 OCT 2010
- Publication data Submitted 16 July 2010 First decision 6 August 2010 Resubmitted 23 September 2010 Accepted 24 September 2010
Aliment Pharmacol Ther 2011; 33: 77–88
Background The association between myocardial infarction (MI) and co-administration of proton pump inhibitors (PPIs) and clopidogrel remains controversial.
Aim To quantify the association between concomitant use of PPIs and clopidogrel and occurrence of recurrent MI.
Methods We conducted a case–control study within a cohort of acute MI patients in PHARMO Record Linkage System (1999–2008). The cases were patients readmitted for MI. PPI exposure was categorized as current (3–1 days before MI), past (30–3 days before MI), or no use (>30 days before MI). We used conditional logistic regression analyses.
Results Among 23 655 patients hospitalized following MI, we identified 1247 patients readmitted for MI. Among clopidogrel users, current PPI use was associated with an increased risk of recurrent MI (OR: 1.62, 95% CI: 1.15–2.27) when compared with no PPI use, but not when compared with past PPI use (OR: 0.95, 95% CI: 0.38–2.41). Among clopidogrel non-users, current PPI use was associated with an increased risk of recurrent MI (OR: 1.38, 95% CI: 1.18–1.61) when compared with no PPI use.
Conclusions The apparent association between recurrent MI and use of PPIs with clopidogrel depends on the design, and is affected by confounding by indication. The association is not present when (un)measured confounding is addressed by design.