Alcohol consumption appears to protect against non-alcoholic fatty liver disease
Article first published online: 1 DEC 2010
© 2010 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 33, Issue 3, pages 378–388, February 2011
How to Cite
Moriya, A., Iwasaki, Y., Ohguchi, S., Kayashima, E., Mitsumune, T., Taniguchi, H., Ikeda, F., Shiratori, Y. and Yamamoto, K. (2011), Alcohol consumption appears to protect against non-alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics, 33: 378–388. doi: 10.1111/j.1365-2036.2010.04520.x
- Issue published online: 4 JAN 2011
- Article first published online: 1 DEC 2010
- Publication data Submitted 28 July 2010 First decision 16 August 2010 Resubmitted 4 November 2010 Accepted 5 November 2010 EV Pub Online 1 December 2010
Aliment Pharmacol Ther 2011; 33: 378–388
Background Moderate alcohol consumption may have certain beneficial effects against non-alcoholic fatty liver disease, which is associated with metabolic syndrome.
Aim To determine the association between drinking pattern and fatty liver in Japanese men and women.
Methods A cross-sectional study was performed with health checkup data including information concerning alcohol consumption and ultrasonographic assessment of fatty liver.
Results We analysed 4957 men and 2155 women without reported liver diseases (median age, 49 years). In men, 40% of nondrinkers and 28% of drinkers had fatty liver. Alcohol consumption was inversely associated with fatty liver (adjusted odds ratio, 0.54; 95% confidence interval, 0.46–0.63). The prevalence of fatty liver in each category of drinking frequency was 38% (1–3 days/week), 29% (4–6 days/week), and 24% (daily drinking); there was a significant inverse correlation between drinking frequency and the prevalence of fatty liver (P < 0.001). In women, 16% of nondrinkers and 10% of drinkers had fatty liver. Drinking less than 20 g on 1–3 days/week was associated with low prevalence of fatty liver (adjusted odds ratio, 0.47; 95% confidence interval, 0.23–0.96).
Conclusions Alcohol consumption appears to protect against non-alcoholic fatty liver disease.