These authors contributed equally to this article.
The effects of pre- and post-pregnancy inflammatory bowel disease diagnosis on birth outcomes
Article first published online: 8 DEC 2010
© 2010 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 33, Issue 3, pages 333–339, February 2011
How to Cite
Raatikainen, K., Mustonen, J., Pajala, M. O., Heikkinen, M. and Heinonen, S. (2011), The effects of pre- and post-pregnancy inflammatory bowel disease diagnosis on birth outcomes. Alimentary Pharmacology & Therapeutics, 33: 333–339. doi: 10.1111/j.1365-2036.2010.04538.x
- Issue published online: 4 JAN 2011
- Article first published online: 8 DEC 2010
- Publication data Submitted 2 March 2010 First decision 6 April 2010 Resubmitted 5 November 2010 Accepted 18 November 2010 EV Pub Online 8 December 2010
Aliment Pharmacol Ther 2011; 33: 333–339
Background Inflammatory bowel diseases are frequent in women at their optimum age for reproduction. Possible effects on pregnancy are therefore of interest.
Aim To assess pregnancy outcomes in 212 women: 135 of whom were diagnosed with inflammatory bowel disease before pregnancy and 77 after pregnancy.
Methods A clinical birth database was examined retrospectively. Odds ratios (ORs) for the main outcomes were calculated with 95% confidence intervals; these were adjusted for confounding factors.
Results Overall, pregnancy outcomes were good. No increased risk of preterm births or need for neonatal intensive care was observed. However, women with inflammatory bowel disease had more growth-retarded newborns, at an adjusted OR of 2.08 (1.26–3.44) and the mode of delivery was more frequently Caesarean section, with an OR of 2.75 (1.82–4.16). In the women who were diagnosed with inflammatory bowel disease after the pregnancy, we found no difference in the obstetric outcome as compared with the general obstetric population.
Conclusions Most women with inflammatory bowel disease have a normal pregnancy outcome and, overall, inflammatory bowel disease during pregnancy poses low-to-moderate risks, the main concern being increased risk of impaired foetal growth. Normal maternal weight gain during pregnancy, possibly indicating a more stable disease, appeared to protect against adverse outcomes.