These authors contributed equally to this work.
Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)
Article first published online: 17 AUG 2011
© 2011 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 34, Issue 8, pages 1020–1029, October 2011
How to Cite
Zhao, Y.-F., Ma, X.-Q., Wang, R., Yan, X.-Y., Li, Z.-S., Zou, D.-W. and He, J. (2011), Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC). Alimentary Pharmacology & Therapeutics, 34: 1020–1029. doi: 10.1111/j.1365-2036.2011.04809.x
- Issue published online: 20 SEP 2011
- Article first published online: 17 AUG 2011
- Publication data Submitted 2 March 2011 First decision 22 March 2011 Resubmitted 12 July 2011 Accepted 22 July 2011
Aliment Pharmacol Ther 2011; 34: 1020–1029
Background The epidemiology and effects of functional constipation (FC) on Chinese people remain unclear.
Aim To investigate the epidemiology of FC and its distinction from constipation-predominant irritable bowel syndrome (IBS-C) in China.
Methods A cross-sectional survey was conducted in a representative adult Chinese population (n = 16 078), which was selected from five regions using randomised, stratified, multistage sampling methodology. All respondents completed the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form (SF-36) and the Epworth Sleepiness Scale (ESS).
Results Overall, 948 respondents (6%) had FC and FC was more prevalent in women than in men (8% vs. 4%, P < 0.001). Straining and hard stools were the two most frequent symptoms. FC was associated significantly with dyspepsia and abdominal bloating. All SF-36 domain scores were lower for respondents with FC than for those without. The prevalence of clinically meaningful daytime sleepiness was significantly higher in respondents with FC than in those without (22% vs. 14%, P = 0.003). Respondents with FC were more likely to strain, but less likely to have a feeling of incomplete emptying after a bowel movement than those with IBS-C. Respondents with IBS-C experienced similar demographics, quality of life and daytime sleepiness to those with FC.
Conclusions The prevalence of FC in China is substantially lower than that in Western countries. FC has negative effects on quality of life and daytime sleepiness. The demographics and burden of illness are similar between FC and IBS-C, although the clinical symptoms are somewhat different.