Early serum HBsAg level as a strong predictor of sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B
Article first published online: 8 JAN 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 35, Issue 4, pages 458–468, February 2012
How to Cite
Peng, C.-Y., Lai, H.-C., Li, Y.-F., Su, W.-P., Chuang, P.-H. and Kao, J.-T. (2012), Early serum HBsAg level as a strong predictor of sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Alimentary Pharmacology & Therapeutics, 35: 458–468. doi: 10.1111/j.1365-2036.2011.04973.x
- Issue published online: 17 JAN 2012
- Article first published online: 8 JAN 2012
- Accepted manuscript online: 6 JAN 2012 12:00AM EST
- Manuscript Accepted: 12 DEC 2011
- Manuscript Revised: 11 DEC 2011
- Manuscript Revised: 16 OCT 2011
- Manuscript Received: 1 OCT 2011
- China Medical University Hospital
The roles remain unclear of early on-treatment quantitative serum HBsAg and hepatitis B virus (HBV) DNA levels in the prediction of a sustained response (SR) to peginterferon alfa-2a therapy in HBeAg-negative chronic hepatitis B (CHB) patients infected with genotype B or C.
To determine their roles in HBeAg-negative CHB patients infected with genotype B or C.
Sixty-one patients were treated with peginterferon alfa-2a for 48 weeks. Serum HBsAg levels were quantified using the Abbott Architect HBsAg QT assay throughout treatment. Multiple regression analyses were performed to identify independent predictors of SR.
Nineteen patients (31%) achieved SR with serum HBV DNA levels <312 copies/mL at 24 weeks post-treatment. Serum HBsAg levels at 12 (OR 31.9; 95% CI 4.8–209.6; P = 0.0003) and 24 weeks of therapy (OR 8.8; 95% CI 2.0–38.0; P = 0.0035), and HBV DNA levels at baseline (OR 7.0; 95% CI 1.3–36.2; P = 0.0203), 12 (OR 7.9; 95% CI 1.2–48.4; P = 0.0249) and 24 weeks of therapy (OR 22.3; 95% CI 2.2–224.0; P = 0.0083) were early independent predictors of SR. A serum HBsAg cut-off of 150 IU/mL at week 12 had an AUC, sensitivity, specificity and positive and negative predictive values of 0.75, 63%, 95%, 86% and 85% with respect to predicting SR respectively.
A quantitative serum HBsAg level at 12 weeks of therapy can be used for the early prediction of SR to peginterferon therapy in HBeAg-negative CHB patients infected with genotype B or C.