As part of AP&T's peer-review process, a technical check of this meta-analysis was performed by Dr P. Collins.
Meta-analysis: diagnostic medical radiation exposure in inflammatory bowel disease
Article first published online: 13 JAN 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 35, Issue 5, pages 529–539, March 2012
How to Cite
Chatu, S., Subramanian, V. and Pollok, R. C. G. (2012), Meta-analysis: diagnostic medical radiation exposure in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 35: 529–539. doi: 10.1111/j.1365-2036.2011.04975.x
- Issue published online: 3 FEB 2012
- Article first published online: 13 JAN 2012
- Manuscript Revised: 13 DEC 2011
- Manuscript Accepted: 13 DEC 2011
- Manuscript Revised: 28 NOV 2011
- Manuscript Received: 9 NOV 2011
Diagnostic imaging plays a pivotal role in the diagnosis and management of inflammatory bowel disease (IBD); however, increasing use has led to concerns about the malignant potential of ionising radiation. Several studies have demonstrated that diagnostic imaging can result in exposure to potentially harmful levels of ionising radiation in IBD patients.
To determine the pooled prevalence of increased exposure and pooled odds ratio of risk factors associated with exposure to potentially harmful levels of diagnostic medical radiation.
We searched Medline, EMBASE, CINHAL and reference lists of identified articles, without language restrictions in October 2011.
Six studies with 1704 participants provided data on the proportion of patients receiving potentially harmful levels of radiation defined as ≥50 milli-sieverts (mSv)-equivalent to 5 CT abdomen scans. The pooled prevalence was 8.8% (95% CI 4.4–16.8) for IBD patients and 11.1% (95% CI 5.7–20.5%) and 2% (95% CI 0.8–4.9%) for Crohn's disease and ulcerative colitis patients respectively. Five studies involving 2627 participants provided data for risk factors. IBD-related surgery and corticosteroid use were significant with pooled adjusted odds ratio of 5.4 (95% CI 2.6–11.2) and 2.4 (95% CI 1.7–3.4) respectively.
About 1 in 10 patients may be exposed to potentially harmful levels of diagnostic medical radiation. Corticosteroid use and IBD related surgery increased this risk. Strategies to reduce radiation exposure while assessing disease activity need to be considered.