Randomised Clinical Trial
Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia
Article first published online: 16 JAN 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 35, Issue 5, pages 552–561, March 2012
How to Cite
Ma, T. T., Yu, S. Y., Li, Y., Liang, F. R., Tian, X. P., Zheng, H., Yan, J., Sun, G. J., Chang, X. R., Zhao, L., Wu, X. and Zeng, F. (2012), Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia. Alimentary Pharmacology & Therapeutics, 35: 552–561. doi: 10.1111/j.1365-2036.2011.04979.x
- Issue published online: 3 FEB 2012
- Article first published online: 16 JAN 2012
- Manuscript Accepted: 17 DEC 2011
- Manuscript Revised: 14 DEC 2011
- Manuscript Revised: 23 FEB 2011
- Manuscript Received: 22 JAN 2011
- National Basic Research Program of China. Grant Number: 2006CB504501
Functional dyspepsia (FD) is a common disease without an established optimal treatment.
To determine (i) the effect of acupuncture in relieving FD symptoms and improving life quality; (ii) the effect difference between acupoint and non-acupoint; and (iii) the effect difference among different acupoints.
A total of 712 eligible patients were included and randomly assigned to six groups (Group A: specific acupoints of the stomach meridian; Group B: non-specific acupoints of the stomach meridian; Group C: specific acupoints of alarm and transport points; Group D: specific acupoints of the gallbladder meridian; Group E: sham acupuncture of non-acupoints; and Group F: itopride). A treatment period of 4 weeks (continuous five sessions per week), and a follow-up period of 12 weeks were arranged. The outcomes were the (i) patients’ response, (ii) symptoms improvement measured using the Symptom Index of Dyspepsia and (iii) quality-of-life improvement based on Nepean Dyspepsia Index.
All groups had an improvement in dyspepsia symptoms and the QoL at the end of treatment, and the improvement was sustained for 4 weeks and 12 weeks. The overall response rate was significantly higher in acupuncture group A (70.69%), and lower in sham acupuncture group (34.75%), compared with itopride and other acupuncture groups. Similarly, the difference in symptoms and QoL improvement was significant between group A and the other acupuncture groups.
Acupuncture is effective in the treatment of functional dyspepsia, and is superior to non-acupoint puncture. The benefit of acupuncture relies on acupoint specificity.