‘Out-patient’ albumin dialysis for cholestatic patients with intractable pruritus
Article first published online: 20 JAN 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 35, Issue 6, pages 696–704, March 2012
How to Cite
Leckie, P., Tritto, G., Mookerjee, R., Davies, N., Jones, D. and Jalan, R. (2012), ‘Out-patient’ albumin dialysis for cholestatic patients with intractable pruritus. Alimentary Pharmacology & Therapeutics, 35: 696–704. doi: 10.1111/j.1365-2036.2012.04994.x
- Issue published online: 20 FEB 2012
- Article first published online: 20 JAN 2012
- Manuscript Accepted: 1 JAN 2012
- Manuscript Revised: 22 DEC 2011
- Manuscript Revised: 21 NOV 2011
- Manuscript Received: 7 NOV 2011
Intractable pruritus is a major problem for some patients with cholestasis. Albumin dialysis has been shown to ameliorate pruritus, but long-term outcome data are limited.
To evaluate the safety and efficacy of ‘out-patient’ albumin dialysis using the molecular adsorbent recirculating system (MARS) in the treatment of intractable pruritus in cholestatic patients referred for liver transplantation for symptomatic relief.
Fifteen patients who failed to respond to standard medical therapy to control pruritus were included. Three MARS (6 h) sessions were performed per admission, and were repeated, if necessary. The intensity and severity of itch was quantified using itch severity and visual analogue scales (ISS and VAS).
Molecular adsorbent recirculating system treatment was safe and associated with immediate and complete response in 11 patients; two patients had a partial response and two patients had no response. Thirty-four treatments were performed during a follow-up period of 15.7 months (3–46) with patients requiring a mean of two admissions (1–6). The mean VAS and ISS improved significantly (both P < 0.001) with improvement in the patient's perception of their quality of life. The duration of acceptable relief in responders was 3.3 months (range 2–5). No serious adverse events were recorded, but the platelet count and haemoglobin were reduced significantly.
Molecular adsorbent recirculating system therapy delivered in an ‘out-patient’ setting is safe and effective with a high degree of patient acceptability. Albumin dialysis can be considered a viable therapeutic option for patients with severe intractable pruritus, in whom, the only other effective treatment option is liver transplantation.