This uncommissioned review article was subject to full peer-review.
Review article: the extra-skeletal effects of vitamin D in chronic hepatitis C infection
Article first published online: 8 FEB 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 35, Issue 6, pages 634–646, March 2012
How to Cite
Cholongitas, E., Theocharidou, E., Goulis, J., Tsochatzis, E., Akriviadis, E. and Burroughs, A. K. (2012), Review article: the extra-skeletal effects of vitamin D in chronic hepatitis C infection. Alimentary Pharmacology & Therapeutics, 35: 634–646. doi: 10.1111/j.1365-2036.2012.05000.x
- Issue published online: 20 FEB 2012
- Article first published online: 8 FEB 2012
- Manuscript Revised: 6 JAN 2012
- Manuscript Accepted: 6 JAN 2012
- Manuscript Revised: 9 OCT 2011
- Manuscript Received: 25 SEP 2011
Recent interest has focused on the extra-skeletal effects of vitamin D, in particular, in patients with chronic hepatitis C.
To review data in the literature regarding the extra-skeletal effects of vitamin D in patients with chronic hepatitis C, with and without liver transplantation.
A Medline search was performed for relevant studies up to August 2011 using the terms ‘vitamin D’ ‘chronic liver disease’ and ‘hepatitis C’.
Vitamin D deficiency is very frequent before liver transplantation ranging between 51% and 92%, whereas, in the liver transplantation setting, the prevalence of vitamin D deficiency is also high. Severe liver disease may increase the risk of vitamin D deficiency and vice versa, as there may be a relationship between vitamin D deficiency and fibrosis. In patients with chronic hepatitis C and those with recurrent of hepatitis C after liver transplantation, recent clinical data shows that a higher serum vitamin D level is an independent predictor of sustained virological response (SVR) following anti-viral therapy, and that a higher SVR is achieved with vitamin D supplementation.
Larger randomised clinical studies with adequate statistical power are needed to confirm these potentially very important nonskeletal effects of vitamin D in patients with chronic hepatitis C.