Original Article

Risk of colorectal adenomas and advanced neoplasia in Hispanic, black and white patients undergoing screening colonoscopy

  1. B. Lebwohl1,2,3,
  2. K. Capiak1,
  3. A. I. Neugut1,2,3,
  4. F. Kastrinos1,2,*

Article first published online: 29 APR 2012

DOI: 10.1111/j.1365-2036.2012.05119.x

Issue

Alimentary Pharmacology & Therapeutics

Alimentary Pharmacology & Therapeutics

Volume 35, Issue 12, pages 1467–1473, June 2012

Additional Information

How to Cite

Lebwohl, B., Capiak, K., Neugut, A. I. and Kastrinos, F. (2012), Risk of colorectal adenomas and advanced neoplasia in Hispanic, black and white patients undergoing screening colonoscopy. Alimentary Pharmacology & Therapeutics, 35: 1467–1473. doi: 10.1111/j.1365-2036.2012.05119.x

Author Information

  1. 1

    Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA

  2. 2

    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA

  3. 3

    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

*Correspondence to:
Dr F. Kastrinos, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA.
E-mail: fk18@columbia.edu

Publication History

  1. Issue published online: 14 MAY 2012
  2. Article first published online: 29 APR 2012
  3. Manuscript Accepted: 13 APR 2012
  4. Manuscript Revised: 11 APR 2012
  5. Manuscript Revised: 27 MAR 2012
  6. Manuscript Received: 4 MAR 2012

Funded by

  • National Cancer Institute. Grant Number: KL2 RR024157
  • National Center for Research Resources
  • National Institutes of Health. Grant Numbers: KL2 RR024157, K07 CA151769-01

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Summary

Background

Racial and ethnic differences in the risk of premalignant colorectal neoplasia have not been extensively studied.

Aim

To measure adenoma prevalence among asymptomatic white, black and Hispanic patients undergoing screening colonoscopy.

Methods

In this cross sectional cohort study, data from individuals ≥50 years undergoing first-time colonoscopy since 2006 at a single tertiary-care medical centre were obtained from the electronic medical record. Adenoma prevalence among whites, blacks and Hispanics was calculated; multivariate Poisson and logistic regression were used to identify factors independently associated with adenoma rates and the presence of advanced adenomas.

Results

We identified 5075 eligible subjects: 3542 (70%) whites, 942 (18%) Hispanics and 591 (12%) blacks. The mean age was 62.2 years with 58% women. At least one adenoma was detected in 19%, 22% and 26% of whites, Hispanics and blacks respectively (Hispanics vs. whites P = 0.09; blacks vs. whites P = 0.0001). Isolated proximal adenomas were present in 9% of whites, 11% of Hispanics (P = 0.03) and 11% of blacks (P = 0.03). In multivariate analyses, a higher rate of adenomas was present in Hispanics (RR: 1.37, 95% CI: 1.20–1.57) and blacks (RR: 1.76, 95% CI: 1.52–2.04) than whites. Hispanics and blacks also had an increased risk of advanced adenomas compared to whites (ORHispanics: 2.25, 95% CI: 1.62–3.11; ORblacks: 1.91, 95% CI: 1.27–2.86).

Conclusions

Adenoma prevalence was higher in blacks and Hispanics than in whites. Both groups were at greater risk of having proximal adenomas in the absence of any distal pathology than whites, where these lesions would have only been detected by colonoscopy. Efforts to promote screening are necessary among diverse, under-represented populations.

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