Endoscopic dilation is an efficacious and safe treatment of intestinal strictures in Crohn's disease
Version of Record online: 21 MAY 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 36, Issue 2, pages 151–158, July 2012
How to Cite
Gustavsson, A., Magnuson, A., Blomberg, B., Andersson, M., Halfvarson, J. and Tysk, C. (2012), Endoscopic dilation is an efficacious and safe treatment of intestinal strictures in Crohn's disease. Alimentary Pharmacology & Therapeutics, 36: 151–158. doi: 10.1111/j.1365-2036.2012.05146.x
- Issue online: 18 JUN 2012
- Version of Record online: 21 MAY 2012
- Manuscript Accepted: 2 MAY 2012
- Manuscript Revised: 12 APR 2012
- Manuscript Revised: 21 MAR 2012
- Manuscript Received: 13 JAN 2012
- The Foundation for Clinical Research in Inflammatory Bowel Disease
- Uppsala-Örebro Regional Research Council
Bowel strictures are a major cause of morbidity, hospitalisation and surgery in Crohn's disease.
We report short- and long-term efficacy and safety of endoscopic balloon dilation of strictures due to Crohn's disease.
Retrospective study of patients who underwent endoscopic balloon dilation between 1987 and 2009.
We performed 776 dilations, of which 621 (80%) were on anastomotic strictures, in 178 patients (94 women) with Crohn's disease. At first dilation, median (IQR) age of patients was 45 (37–56) years and disease duration 16 (8–22) years. Technical success rate was 689/776 (89%). A subset of 75 patients from the primary catchment area, with >5-year follow-up, underwent a total of 246 dilations. At 1-year follow-up, 60/75 (80%) patients had undergone no further intervention or one additional dilation only. At 3 and 5 years, corresponding figures were 43/75 (57%) and 39/75 (52%). Cumulative proportions of patients undergoing surgery at 1, 3 and 5 years were 13%, 28% and 36%. Complication rate per procedure for all 178 patients was 41/776 (5.3%), bowel perforation (n = 11, 1.4%), major bleeding requiring blood transfusion (n = 8, 1.0%), minor bleeding (n = 10, 1.3%) and abdominal pain or fever (n = 12, 1.5%). Ten patients underwent surgery due to complications (perforation n = 8, bleeding n = 2). There was no procedure-related mortality.
Endoscopic balloon dilation is an efficacious and safe alternative to surgical resection of intestinal strictures in Crohn's disease. At 5-year follow-up, 52% of patients required no further or one additional dilation only, whereas 36% had undergone surgical resection. Complication frequency was low.