The haemodynamic effects of intravenous induction

Comparison of the effects of thiopentone and propofol

Authors

  • R. M. GROUNDS,

    1. R.M. Grounds, FFARCS, Senior Registrar, A.J. Twigley, FFARCS, Senior Registrar, F. Carli, FFARCS, Senior Registrar, J.G. Whitwam, PhD, FRCP, FFARCS, Professor of Clinical Anaesthesia, M. Morgan, FFARCS, Reader in Anaesthetic Practice, Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS.
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  • A.J. TWIGLEY,

    1. R.M. Grounds, FFARCS, Senior Registrar, A.J. Twigley, FFARCS, Senior Registrar, F. Carli, FFARCS, Senior Registrar, J.G. Whitwam, PhD, FRCP, FFARCS, Professor of Clinical Anaesthesia, M. Morgan, FFARCS, Reader in Anaesthetic Practice, Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS.
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  • F. CARLI,

    1. R.M. Grounds, FFARCS, Senior Registrar, A.J. Twigley, FFARCS, Senior Registrar, F. Carli, FFARCS, Senior Registrar, J.G. Whitwam, PhD, FRCP, FFARCS, Professor of Clinical Anaesthesia, M. Morgan, FFARCS, Reader in Anaesthetic Practice, Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS.
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  • J. G. WHITWAM,

    1. R.M. Grounds, FFARCS, Senior Registrar, A.J. Twigley, FFARCS, Senior Registrar, F. Carli, FFARCS, Senior Registrar, J.G. Whitwam, PhD, FRCP, FFARCS, Professor of Clinical Anaesthesia, M. Morgan, FFARCS, Reader in Anaesthetic Practice, Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS.
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  • M. MORGAN

    1. R.M. Grounds, FFARCS, Senior Registrar, A.J. Twigley, FFARCS, Senior Registrar, F. Carli, FFARCS, Senior Registrar, J.G. Whitwam, PhD, FRCP, FFARCS, Professor of Clinical Anaesthesia, M. Morgan, FFARCS, Reader in Anaesthetic Practice, Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS.
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Summary

The haemodynamic changes following induction of anaesthesia with equipotent doses of propofol and thiopentone have been compared. Propofol caused a significant fall in arterial blood pressure and total peripheral resistance, with a slight fall in cardiac output. There were no changes in heart rate. Apart from an initial, but statistically insignificant increase in heart rate, similar changes were produced by thiopentone, but to a lesser degree. It is concluded that induction of anaesthesia with propofol results in acceptable haemodynamic changes, but that the agent is more depressant to the cardiovascular system than thiopentone.

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