Propofol for induction and maintenance of anaesthesia at Caesarean section A comparison with thiopentone/enflurane

Authors

  • G. YAU,

    1. G. Yau, MB, BS, FFARCS, T. Gin, MB, ChB, BSc, FFARCS, FFARACS, Lecturers, C.F. Kotur, MB, BS, DA, FFARCS, Honorary Clinical Lecturer, T.E. Oh, MB, BS, FFARCS, FFARACS, Professor, Department of Anaesthesia and Intensive Care, R.K.W. Leung, MB, BS, MRCP, Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, M.C. Ewart, MB, BS, FFARCS, Senior Registrar, Hammersmith Hospital, Du Cane Road, London W12 0NN.
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  • T. GIN,

    1. G. Yau, MB, BS, FFARCS, T. Gin, MB, ChB, BSc, FFARCS, FFARACS, Lecturers, C.F. Kotur, MB, BS, DA, FFARCS, Honorary Clinical Lecturer, T.E. Oh, MB, BS, FFARCS, FFARACS, Professor, Department of Anaesthesia and Intensive Care, R.K.W. Leung, MB, BS, MRCP, Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, M.C. Ewart, MB, BS, FFARCS, Senior Registrar, Hammersmith Hospital, Du Cane Road, London W12 0NN.
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  • M. C. EWART,

    1. G. Yau, MB, BS, FFARCS, T. Gin, MB, ChB, BSc, FFARCS, FFARACS, Lecturers, C.F. Kotur, MB, BS, DA, FFARCS, Honorary Clinical Lecturer, T.E. Oh, MB, BS, FFARCS, FFARACS, Professor, Department of Anaesthesia and Intensive Care, R.K.W. Leung, MB, BS, MRCP, Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, M.C. Ewart, MB, BS, FFARCS, Senior Registrar, Hammersmith Hospital, Du Cane Road, London W12 0NN.
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  • C. F. KOTUR,

    1. G. Yau, MB, BS, FFARCS, T. Gin, MB, ChB, BSc, FFARCS, FFARACS, Lecturers, C.F. Kotur, MB, BS, DA, FFARCS, Honorary Clinical Lecturer, T.E. Oh, MB, BS, FFARCS, FFARACS, Professor, Department of Anaesthesia and Intensive Care, R.K.W. Leung, MB, BS, MRCP, Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, M.C. Ewart, MB, BS, FFARCS, Senior Registrar, Hammersmith Hospital, Du Cane Road, London W12 0NN.
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  • R. K. W. LEUNG,

    1. G. Yau, MB, BS, FFARCS, T. Gin, MB, ChB, BSc, FFARCS, FFARACS, Lecturers, C.F. Kotur, MB, BS, DA, FFARCS, Honorary Clinical Lecturer, T.E. Oh, MB, BS, FFARCS, FFARACS, Professor, Department of Anaesthesia and Intensive Care, R.K.W. Leung, MB, BS, MRCP, Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, M.C. Ewart, MB, BS, FFARCS, Senior Registrar, Hammersmith Hospital, Du Cane Road, London W12 0NN.
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  • T. E. OH

    1. G. Yau, MB, BS, FFARCS, T. Gin, MB, ChB, BSc, FFARCS, FFARACS, Lecturers, C.F. Kotur, MB, BS, DA, FFARCS, Honorary Clinical Lecturer, T.E. Oh, MB, BS, FFARCS, FFARACS, Professor, Department of Anaesthesia and Intensive Care, R.K.W. Leung, MB, BS, MRCP, Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, M.C. Ewart, MB, BS, FFARCS, Senior Registrar, Hammersmith Hospital, Du Cane Road, London W12 0NN.
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Summary

A propofol infusion regimen and a standard general anaesthetic were compared in 40 Chinese women undergoing elective Caesarean section. Twenty patients received propofol 2 mg/kg for induction of anaesthesia followed by propofol 6 mg/kg/hour, while 20 patients received thiopentone 4 mg/kg with enflurane 1% for maintenance of anaesthesia. All patients were given atracurium and their lungs ventilated with nitrous oxide 50% in oxygen until delivery of the neonate. The hypertensive response after intubation was of shorter duration in the propofol group compared with the thiopentone group. Induction to delivery times ranged from 5 to 14 minutes and neonates from both groups had similar and satisfactory Apgar scores, Neurologic and Adaptive Capacity Scores and umbilical cord blood gas analysis. However, a prolonged propofol infusion time before delivery may cause lower Neurologic and Adaptive Capacity Scores. There were no differences in maternal recovery times or psychomotor performance.

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