Ketamine as analgesic for total intravenous anaesthesia with propofol
Article first published online: 22 FEB 2007
Volume 46, Issue 1, pages 24–27, January 1991
How to Cite
GUIT, J. B. M., KONING, H. M., COSTER, M. L., NIEMEIJER, R. P. E. and MACKIE, D. P. (1991), Ketamine as analgesic for total intravenous anaesthesia with propofol. Anaesthesia, 46: 24–27. doi: 10.1111/j.1365-2044.1991.tb09308.x
- Issue published online: 22 FEB 2007
- Article first published online: 22 FEB 2007
- Accepted 4 June 1990.
- Total intravenous anaesthesia;
- Anaesthetics, intravenous; propofol, ketamine
A prospective study of 18 patients who underwent noncardiac surgery was performed to study the use of ketamine as an analgesic during total intravenous anaesthesia with propofol. A comparison was made with the combination propofol/fentanyl. The propofol/ketamine combination resulted in haemodynamically stable anaesthesia without the need for additional analgesics. Postoperative behaviour was normal in all patients and none of the patients reported dreaming during or after the operation. Propofol seems to be effective in eliminating side effects of a subanaesthetic dose of ketamine in humans. We recommend the propofol/ketamine combination for total intravenous anaesthesia for surgery when stable haemodynamics are required.