The TEG® vs the ROTEM® thromboelastography/thromboelastometry systems



This article is corrected by:

  1. Errata: Corrigendum Volume 64, Issue 11, 1272, Article first published online: 9 October 2009

  • Editorial note: This is the first in what we hope will be a regular feature in Anaesthesia, in which two or more pieces of equipment are compared alongside each other, from the point of view of the practical user. We welcome submissions on other equipment/apparatus, following a similar format to that below; please title your manuscript ‘Head-to-head’. All submitted manuscripts will undergo the same review process as for other articles submitted to Anaesthesia.

Dr Keri Ashpole


We have evaluated the TEG® thromboelastograph and the ROTEM® thromboelastometer, two point-of-care devices that measure blood coagulation. During a one-week period, seven consultant anaesthetists, one consultant haematologist, one associate specialist anaesthetist and two senior trainee anaesthetists were trained by the manufacturers and set up, calibrated and used both systems, after which their views were obtained and specific technical/support information was sought from the manufacturers using a questionnaire. Although the devices shared common features, they differed in complexity and aspects of ease of use, and in their purchase and running costs.

A number of devices for point-of care testing of coagulation are now available and of these, the TEG® thromboelastograph (Haemoscope Corporation, Niles, IL, USA; Fig. 1) and the ROTEM® thromboelastometer (Pentapharm GmbH, Munich, Germany; Fig. 2) systems are amongst the best known. Both measure coagulation by assessing the shear elasticity of blood as it clots; the principles have been described elsewhere [1] but in brief, both employ a vertical pin held in the blood sample, contained within a cup or cuvette. In the TEG®, the cup oscillates clockwise and anticlockwise and as the blood clots, fibrin strands and platelet aggregates form between the pin and the inner walls of the cup, resulting in torque on the pin that is monitored and converted to an electrical signal. In the ROTEM®, an oscillatory force is applied to the pin and the cuvette is held stationary; as the blood clots, the extent of the pin’s actual oscillation is reduced and this is measured by the angle of deflection of a beam of light directed at the pin. We were interested in ‘road testing’ both devices with a view to a possible purchase, and here present our findings as an aid to other departments undergoing a similar process.

Figure 1.

 The TEG® thromboelastography system. Two units are shown on the right of the separate (but connected) laptop computer, each with two sampling channels.

Figure 2.

 The ROTEM® thromboelastometry system. The touch-sensitive screen, automated pipette, sampling channels (labelled 1–4) and reagent tray (front) are shown.


Both devices were installed on our labour ward for the same one-week period, during which time the UK representatives of both were present to train staff and provide support. During the trial period, seven consultant anaesthetists, one consultant haematologist, one associate specialist anaesthetist and two senior trainee anaesthetists participated in the evaluation, which included setting up/calibrating the machines and running tests on volunteer blood samples given by certain of the evaluators. (The Local Research Ethics Committee chairman was approached for advice before evaluation and considered a formal application unnecessary. All participants were aware of the implications of testing including issues around confidentiality). Assessment was semi-structured in that the features of the devices were categorised as indicated in the Table and opinions sought from all participants, both verbal and written. Following the trial period, a questionnaire was sent to the two companies to seek specific technical and support information.


The information supplied by the manufacturers (correct as of August 2008) and the overall opinions/comments of the evaluators are shown in Table 1.

Table 1.   Features of the ROTEM® thromboelastometry and TEG® thromboelastography systems, and the pooled opinions/comments of the assessors.
  1. *Height × width × depth.

DescriptionEach 2-channel unit 29 × 19 × 23 cm;* separate computer and colour inkjet printer supplied. Runs in Windows XP®57 × 37 × 57 cm; integral computer with touch-sensitive screen. Printer supplied at ∼£68 extra. Runs in Linux
Requirements for sitingElectrical point ± network point Level workbench; vibration freeElectrical point ± network point
Warm-up timeFrom ‘cold’ < 5 min; from ‘standby’ nilFrom ‘cold’ 5–15 min; from ‘standby’ 1 min
Calibration/quality control (QC)Daily checks: level positioning and machine check (both 2 min; no cost)Constantly running internal QC; no daily test required (no cost)
No extra weekly testing requiredWeekly formal QC required (∼£22; ∼30 min)
Monthly QC required (∼£17; ∼20 min)No extra monthly testing required
If QC out of range: repeat test; contact office; further action depends on contractAs for TEG®
Tests/reagents‘Routine’ test must be run within 4 min if sample is not anticoagulated (if citrated sample wait 30 min; must add calcium)Advised to run two tests, INTEM and EXTEM (test internal and external pathways), for each patient. Citrated sample always used but may be used immediately
Other tests possible: heparinase, functional fibrinogen, platelet mapping. Can detect effect of low molecular weight heparinOther tests possible as for TEG® except for platelet mapping. Cannot detect effect of low molecular weight heparin
Single-use vials used for all tests; shelf life 6–12 monthsMulti-use vials used (though may be replaced by single-use); shelf life once opened 8–30 days depending on the test.
PipettesManual pipettes required, 10–360 μlAutomatic pipette; 2 × 20 μl reagent per test
Reference rangesAble to set own ranges and/or add two sets of rangesAble to set own ranges
ResultsCan superimpose results, set obligatory fields, set automatic backup, or export to xls formatCan superimpose results, set obligatory fields, set automatic backup, or export to xls/txt/jpeg formats
Output via USB port or networked (wireless connectivity possible)Output via USB port or networked (wireless connectivity not currently possible)
List price£13 500 (two channel unit, analyser, PC/laptop, printer, software, cables, pipettes, 8+ days’ on-site training, 1-year guarantee and on-site servicing)
£26 000 (4 channel unit + as above)
£21 662 (standard 4 channel, integrated PC, analyser, monitor, software, cables, pipettes, 3 days’ on-site training, 2-year guarantee and on-site servicing)
Cost of reagentsKaolin vials (for standard testing) £2.52 each; functional fibrinogen £8.33 each; platelet function £70 eachVariable according to test (£0.29- £2.68 per test)
Cost of cup + pinPlain cup £5.05, heparinase cup £10.15Cup £3.09
Cost of running one ‘basic’ testKaolin vial + plain cup; total £7.57 (only one cup/channel is required for a ‘basic’ test)Reagents £2.64 + 2 cups £6.19; total £8.83 (two cups/ channels are required for a ‘basic’ test). It should be noted that due to the multiuse vials the cost per test would increase if any reagent were wasted e.g. if expired
Aftercare costsYearly maintenance/wear/breakdown cover & service £2000/year (for 2-channel single unit; £1700 for each additional unit)
If no aftercare contract: £300 callout + £120/h labour + parts
Yearly maintenance/wear ∼£1081/year; increases to £1400/year with breakdown cover
If no aftercare contract: annual service included for 2 years while under guarantee; variable thereafter
If machine failsOn-site repair aimed for; replacement provided within 48 h or 72 h according to level of coverOn-site repair aimed for; replacement provided next working day
TrainingMinimum 2 days on-site with 24-h on-call facility; as many follow-up training days as required in first 6 months; one day per month for next 6 months if required
Tutorial book and sign-off exam
Two days on-site + 1 refresher day for four operators; any further training £1500/day plus expenses
Summary and general opinion of assessorsAdvantages: cheaper; well known and more widespread use in UK; therefore more extensive literature; good training programme and service support; screen easier to follow and appearance preferred; good technical support; can see other results while running test; Windows software; can look at effect of low molecular weight heparin
Disadvantages: two channels per machine (though a ‘basic’ test requires only one channel); exporting results less flexible; manual pipetting possibly more prone to error (though automated available); more prone to vibration (though this was tested and the integral compensation software found to be effective)
Advantages: integrated system; more resistant to vibration; automatic pipetting; easy step-by-step on-screen instructions; four channels per machine (though a ‘basic’ test requires two channels)
Disadvantages: more expensive; less well known in UK; less attractive training programme; bulky appearance, detachable small parts which could be lost; more complicated tests requiring multiple reagents; complicated screen options; cannot see other results while running test; Linux software; cannot look at effect of low molecular weight heparin. Running costs may be increased for the occasional user; otherwise comparable


Readers will be familiar with the ‘head-to-head’ format that is popular with reviews of non-medical items such as computers, cars and household appliances, whilst medical reviews have tended to be of single items, focused on scientific principles, or based on statistical comparisons of performance. We felt a need for a more practical approach, which we feel represents more closely the process undertaken within anaesthetic departments. We accept that our assessments and conclusions are subjective, but the information/specifications on which they are based are as accurate as we can obtain, and the opinions/comments were remarkably consistent amongst the assessors. The overall conclusion was that the TEG® represented the best compromise between usability, usefulness and cost, currently – although even the lesser amount required represents a significant challenge for our department and the merits of having access to such a device [2], when compared with other financial priorities, is still the subject of some discussion.


We are grateful to the manufacturers, distributors and representatives for their help and support in facilitating this evaluation. KA has previously undertaken research involving the ROTEM® while undertaking a research fellowship funded by Smiths Medical Inc, Keane, NH, USA and did not participate in the evaluation.