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Genetic polymorphisms of the bovine Fatty acid binding protein 4 gene are significantly associated with marbling and carcass weight in Hanwoo (Korean Cattle)

Authors

  • S. H. Lee,

    1. Animal Genome & Bioinformatics Division, National Institute of Animal Science, RDA, Suwon 441-701, Korea
    2. The Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, NSW 2351, Australia
    3. School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia
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  • J. H. J. Van Der Werf,

    1. School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia
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  • S. H. Lee,

    1. Queensland Institute of Medical Research, Brisbane, Qld 4029, Australia
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  • E. W. Park,

    1. Animal Genome & Bioinformatics Division, National Institute of Animal Science, RDA, Suwon 441-701, Korea
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  • S. J. Oh,

    1. Animal Genome & Bioinformatics Division, National Institute of Animal Science, RDA, Suwon 441-701, Korea
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  • J. P. Gibson,

    1. The Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, NSW 2351, Australia
    2. School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia
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  • J. M. Thompson

    1. The Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, NSW 2351, Australia
    2. School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia
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E. W. Park, National Institute of Animal Science, RDA, 564 Omokchun-dong Suwon 441-350, Korea
E-mail: pewkys@korea.kr

Summary

The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs [g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT (P = 0.01) and the g.3631G allele was associated with higher marbling score (P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT (P = 0.02) and marbling score (P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg).

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