The oral retention and antiplaque efficacy of triclosan in human volunteers.
Article first published online: 26 JUL 2012
1987 The British Pharmacological Society
British Journal of Clinical Pharmacology
Volume 23, Issue 5, pages 579–583, May 1987
How to Cite
Gilbert, R. and Williams, P. (1987), The oral retention and antiplaque efficacy of triclosan in human volunteers. British Journal of Clinical Pharmacology, 23: 579–583. doi: 10.1111/j.1365-2125.1987.tb03094.x
- Issue published online: 26 JUL 2012
- Article first published online: 26 JUL 2012
An antiplaque toothpaste containing 0.2% (w/w) triclosan significantly inhibited overnight plaque growth in 12 human volunteers. After use of a 1 g quantity of the toothpaste containing 0.2% (w/w) [3H]-triclosan, 36.3 +/- 1.4% of the triclosan was retained. The mean concentration (+/- s.d.) achieved in saliva 5 min after toothpaste use was 8.16 +/- 2.50 micrograms g-1. The saliva decay curve for triclosan was consistent with a two phase model with t1/2 values of 0.45 h and 2.42 h, respectively. Triclosan was present in bacterial plaque for at least 8 h after dosage and in the oral mucosa for at least 3 h.