Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration.
Article first published online: 5 JUL 2012
1993 The British Pharmacological Society
British Journal of Clinical Pharmacology
Volume 36, Issue 2, pages 125–127, August 1993
How to Cite
Pollak, P., Sharma, A. and Carruthers, S. (1993), Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration. British Journal of Clinical Pharmacology, 36: 125–127. doi: 10.1111/j.1365-2125.1993.tb04207.x
- Issue published online: 5 JUL 2012
- Article first published online: 5 JUL 2012
Serum creatinine and drug concentrations were measured at 0, 1, 2, 3, 6, 9 and 12 months in 30 consecutive patients started on amiodarone. In 28 of these patients with no obvious cause for altered renal function, mean serum creatinine increased to 11% above baseline (P < 0.005). Rising creatinine concentrations correlated with amiodarone concentrations (y = 93.9 + 8.6x, r = 0.51, P < 0.0001). When assessing elevation of serum creatinine in a patient receiving amiodarone, physicians should be aware that it may be related to this drug.