The Clinical Pharmacology of Ageing, edited by Dr A.A. Mangoni and colleagues, Department of Healthcare for the Elderly, Guy’s, King's and St Thomas’ School of Medicine, Kings College London, London, UK.
Drug metabolism and ageing
Article first published online: 16 APR 2004
British Journal of Clinical Pharmacology
Volume 57, Issue 5, pages 540–544, May 2004
How to Cite
Kinirons, M. T. and O'Mahony, M. S. (2004), Drug metabolism and ageing. British Journal of Clinical Pharmacology, 57: 540–544. doi: 10.1111/j.1365-2125.2004.02096.x
- Issue published online: 16 APR 2004
- Article first published online: 16 APR 2004
- Received 28 August 2003 Accepted 1 September 2003
Important changes in drug metabolism occur with ageing. Age-associated reductions in function of some but not all cytochrome P450 enzymes (CYPs) have been described. Induction and inhibition of CYPs needs to be revisited in light of recent advances. The function and pharmacology of transporters have not yet been examined for an age-related effect. Finally, the concept of frailty is being underpinned by studies documenting a decline in drug metabolism and changes in disposition in frail older people compared with either healthy elderly or the young.