SEARCH

SEARCH BY CITATION

Keywords:

  • diabetes;
  • hypertension;
  • spironolactone

Aims

To assess whether spironolactone has beneficial effects on blood pressure (BP), N-terminal propeptide of type III procollagen (PIIINP) and pulse wave velocity (PWV) in hypertensive, type II diabetics.

Methods

Ten patients with type II diabetes and hypertension were enrolled in a randomized, double-blind crossover study comparing 4 months’ treatment with spironolactone and placebo with a 4-week washout phase. BP, PIIINP and carotid-radial PWV were measured at the end of each treatment phase.

Results

Compared with placebo, spironolactone reduced systolic BP by 15.6 ± 46.1 mmHg (P = 0.005, 95% CI 2.7–28.5 mmHg), PIIINP by 0.6 ± 0.3 µg l−1 (P = 0.04, 95% CI 0.02–1.1 µg l−1) and PWV by 0.6 ± 0.2 m s−1 (P = 0.008, 95% CI 0.18–1.02 m s−1).

Conclusions

Spironolactone is effective at reducing systolic BP and brachial artery stiffness as indicated by PWV. It also reduces PIIINP in type II diabetic patients with hypertension.