Predicting sustained virological response and anaemia in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD) plus ribavirin
Article first published online: 16 AUG 2006
British Journal of Clinical Pharmacology
Volume 62, Issue 6, pages 699–709, December 2006
How to Cite
Snoeck, E., Wade, J. R., Duff, F., Lamb, M. and Jorga, K. (2006), Predicting sustained virological response and anaemia in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD) plus ribavirin. British Journal of Clinical Pharmacology, 62: 699–709. doi: 10.1111/j.1365-2125.2006.02741.x
- Issue published online: 16 AUG 2006
- Article first published online: 16 AUG 2006
- Received 14 December 2005 Accepted27 June 2006 Published OnlineEarly16 August 2006
- hepatitis C;
- peginterferon alfa-2a (40KD);
- sustained virological response
To assess the likelihood of a sustained virological response (SVR) vs. the likelihood of anaemia in patients with chronic hepatitis C.
Data from 1732 patients treated with peginterferon alfa-2a (40KD) plus ribavirin in two randomized, multinational studies were pooled. Probabilities of SVR and anaemia were modelled using the generalized additive logistic model, with numerous clinical variables considered for entry into the model. Baseline haemoglobin was only considered in the analysis for anaemia.
The probability of anaemia increased from 6 to 16% as a function of the ribavirin dose kg−1 (12–16 mg kg−1), whereas the relationship between SVR and ribavirin dose kg−1 was influenced by hepatitis C virus (HCV) genotype. The probability of an SVR was not influenced by the ribavirin dose kg−1 in patients with HCV genotype 2 or 3 infection, but increased as a function of ribavirin dose kg−1 in patients with HCV genotype 1 infection (40–50% increase in probability of SVR for 12–16 mg kg−1 dose ribavirin increase). The probability of an SVR in patients included with HCV genotype 1 decreased with increasing HCV RNA level to about 3 million copies ml−1, but was relatively independent of increasing HCV RNA level thereafter. In addition, older age, a higher ribavirin apparent oral clearance and cirrhosis had a negative impact on achieving an SVR, but improved with increasing alanine aminotransferase (ALT) quotient. Sex and ribavirin dose kg−1 were the most important prognostic factors for anaemia, followed by baseline haemoglobin, age, baseline ALT quotient and cirrhosis.
This study supports individualizing ribavirin dosages by HCV genotype and body weight, and highlights several clinical variables that influence the likelihood of an SVR compared with anaemia in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD) plus ribavirin.