Pharmacogenetics of aspirin resistance: a comprehensive systematic review
Version of Record online: 22 APR 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
British Journal of Clinical Pharmacology
Volume 66, Issue 2, pages 222–232, August 2008
How to Cite
Goodman, T., Ferro, A. and Sharma, P. (2008), Pharmacogenetics of aspirin resistance: a comprehensive systematic review. British Journal of Clinical Pharmacology, 66: 222–232. doi: 10.1111/j.1365-2125.2008.03183.x
- Issue online: 14 JUL 2008
- Version of Record online: 22 APR 2008
- Received21 December 2007Accepted14 March 2008Published OnlineEarly22 April 2008
- aspirin resistance;
- systematic review
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
• A genetic basis for aspirin resistance has been postulated to exist.
• The individual studies published have been too small to allow reliable conclusions to be drawn.
• In order to clarify what, if any, genetic basis exists for aspirin resistance, we have undertaken, to our knowledge, the largest and most comprehensive systematic review conducted to-date in this field.
WHAT THIS STUDY ADDS
• There is a significant association between the PlA1/A2 molecular variant and aspirin resistance in healthy subjects, with the effect diminishing in the presence of cardiovascular disease.
• However further studies are needed to confirm this.
• We argue that investigators now need to agree on a standard technique to measure and define aspirin resistance.
AIMS The aim was to perform a systematic review of all candidate gene association studies in aspirin resistance.
METHODS Electronic databases were searched up until 1 December 2007 for all studies investigating any candidate gene for aspirin resistance in humans. Aspirin resistance was required to have been measured by a standardized laboratory technique to be included in the analysis.
RESULTS Within 31 studies, 50 polymorphisms in 11 genes were investigated in 2834 subjects. The PlA1/A2 polymorphism in the GPIIIa platelet receptor was the most frequently investigated, with 19 studies in 1389 subjects. The PlA1/A2 variant was significantly associated with aspirin resistance when measured in healthy subjects [odds ratio (OR) 2.36, 95% confidence interval (CI) 1.24, 4.49; P = 0.009]. Combining genetic data from all studies (comprising both healthy subjects and those with cardiovascular disease) reduced the observed effect size (OR 1.14, 95% CI 0.84, 1.54; P = 0.40). Moreover, the observed effect of PlA1/A2 genotype varied depending on the methodology used for determining aspirin sensitivity/resistance. No significant association was found with aspirin resistance in four other investigated polymorphisms in the COX-1, GPla, P2Y1 or P2Y12 genes.
CONCLUSIONS Our data support a genetic association between the PlA1/A2 molecular variant and aspirin resistance in healthy subjects, with the effect diminishing in the presence of cardiovascular disease. The laboratory methodology used influences the detection of aspirin resistance. However, as heterogeneity was significant and our results are based on a limited number of studies, further studies are required to confirm our findings.