You have full text access to this OnlineOpen article
Acute amiodarone toxicity due to an administration error: could excipient be responsible?
Article first published online: 15 OCT 2008
DOI: 10.1111/j.1365-2125.2008.03323.x
© 2008 The Authors. Journal compilation © 2008 The British Pharmacological Society
Additional Information
How to Cite
Masi, S., De Cléty, S. C., Anslot, C. and Detaille, T. (2009), Acute amiodarone toxicity due to an administration error: could excipient be responsible?. British Journal of Clinical Pharmacology, 67: 691–693. doi: 10.1111/j.1365-2125.2008.03323.x
Publication History
- Issue published online: 25 JUN 2009
- Article first published online: 15 OCT 2008
- RECEIVED 5 June 2008; ACCEPTED 25 September 2008
REFERENCES
- 1, , . Amiodarone. An overview of its pharmacological properties and review of its therapeutic use in cardiac arrythmias. Drugs 1992; 43: 69–110.
- 2, , , , , , . A randomised haemodynamic comparison of intravenous amiodarone with and without Tween 80®. Eur Heart J 1988; 9: 142–8.
- 3, , , . Hypotensive action of commercial intravenous amiodarone and polysorbate 80 in dogs. J Cardiovasc Pharmacol 1982; 4: 375–80.
- 4, , . Antiarrythmic effects of solvents: effects of propylene glycol and benzyl alcohol on contractile force of isolated rabbit heart. Cardiovasc Res 1979; 13: 717–22.
- 5, , , . Parenteral toxicity studies with benzyl alcohol. Toxicol Appl Pharmacol 1971; 18: 60.
- 6Center for Disease Control and Prevention. Neonatal deaths associated with use of benzyl alcohol – United States. MMWR Morb Mortal Wkly Rep 1982; 31: 290–1.
- 7, , , , . Fatal benzyl alcohol poisoning in a neonatal intensive care unit. Lancet 1982; 1: 1250.
- 8, , , , . Haemodynamic and surface electrocardiographic effects of a new aqueous formulation of intravenous amiodarone. Am J Cardiol 2002; 90: 964–8.
- 9, , , . Comparative effects of rapid administration of aqueous amiodarone vs 10-min cordarone IV infusion on mean arterial blood pressure in conscious dogs. Cardiovasc Drugs Ther 2004; 18: 345–51.
- 10, , , , . Negative inotropic and lusotropic effects of intravenous amiodarone in conscious rats. Clin Exp Pharmacol Physiol 2007; 34: 870–5.
- 11, , , , , , , , , , , . Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone. Am J Cardiol 2004; 93: 576–81.
- 12, , . Efficacy and safety of IV amiodarone for incessant tachycardias in infants. Eur J Pediatr 2003; 162: 880–4.

1365-2125/asset/olbannerleft.gif?v=1&s=e86b92cac3efbbd2e255b9fa97ece9623eac0b54)
1365-2125/asset/olbannerright.gif?v=1&s=6a7c47d290382bf3bc40c62461bc36a371a081bf)
