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REFERENCES

  • 1
    Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell 1998; 94: 65766.
  • 2
    Tschopp TB, Weiss HJ, Baumgartner HR. Decreased adhesion of platelet to subendothelium in von Willebrand's disease. J Lab Clin Med 1973; 83: 296300.
  • 3
    Weiss HJ, Turitto VT, Baumgartner HR. Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate-dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome. J Lab Clin Med 1978; 92: 75064.
  • 4
    Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF. The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering. J Cell Biol 1987; 104: 165563.
  • 5
    Siess W. Molecular mechanisms of platelet activation. Physiol Rev 1989; 69: 58178.
  • 6
    Semple JW, Freedman JE. Platelets and innate immunity. Cell Mol Life Sci 2010; 67: 499511.
  • 7
    Kroll MH, Hellums JD, McIntire LV, Schafer AI, Moake JL. Platelets and shear stress. Blood 1996; 88: 152541.
  • 8
    Freedeman JE, Loscalzo J. Platelet–monocyte aggregates: bridging thrombosis and inflammation. Circulation 2002; 105: 21302.
  • 9
    Michelson D, Barnard MR, Krueger LA, Valeri CR, Furman MI. Circulating monocyte–platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet P-selectin: studies in baboons, human coronary intervention, and human myocardial infarction. Circulation 2001; 104: 15337.
  • 10
    Sarma J, Laan CA, Alam S, Jha A, Fox KA, Dransfield I. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 2002; 105: 216671.
  • 11
    Furman MI, Barnard MR, Krueger LA, Fox ML, Shilale EA, Lessard DM, Marchese P, Frelinger A. L, 3rd, Goldberg RJ, Michelson AD. Circulating monocyte–platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol 2001; 38: 10026.
  • 12
    Marquardta L, Andersb C, Bugglea F, Palma F, Hellsternb P, Graua AJ. Leukocyte–platelet aggregates in acute and subacute ischemic stroke. Cerebrovasc Dis 2009; 28: 27682.
  • 13
    Joseph JE, Harrison P, Mackie IJ, Isenberg DA, Machin SJ. Increased circulating platelet–leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis. Br J Haematol 2001; 115: 4519.
  • 14
    Jensen MK, de Nully Brown P, Lund BV, Nielsen OJ, Hasselbalch HC. Increased circulating platelet–leukocyte aggregates in myeloproliferative disorders is correlated to previous thrombosis, platelet activation and platelet count. Eur J Haematol 2001; 66: 14351.
  • 15
    Wun T, Cordoba M, Rangaswami A, Cheung AW, Paglieroni T. Activated monocytes and platelet–monocyte aggregates in patients with sickle cell disease. Clin Lab Haematol 2002; 24: 818.
  • 16
    Gkaliagkousi E, Corrigall V, Becker S, de Winter P, Shah A, Zamboulis C, Ritter J, Ferro A. Decreased platelet nitric oxide contributes to increased circulating monocyte–platelet aggregates in hypertension. Eur Heart J 2009; 30: 304854.
  • 17
    Harding SA, Sarma J, Josephs DH, Cruden NL, Din JN, Twomey PJ, Fox KA, Newby DE. Upregulation of the CD40/CD40 ligand dyad and platelet–monocyte aggregation in cigarette smokers. Circulation 2004; 109: 19269.
  • 18
    Harding SA, Sommerfield AJ, Sarma J, Twomey PJ, Newby DE, Frier BM, Fox KA. Increased CD40 ligand and platelet–monocyte aggregates in patients with type 1 diabetes mellitus. Atherosclerosis 2004; 176: 3215.
  • 19
    Klinkhardt U, Bauersachs R, Adams J, Graff J, Lindhoff-Last E, Harder S. Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet–leukocyte aggregates in patients with atherosclerotic vascular disease. Clin Pharmacol Ther 2003; 73: 23241.
  • 20
    Furie B, Furie BC. Thrombus formation in vivo. J Clin Invest 2005; 115: 335562.
  • 21
    Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 2003; 9: 617.
  • 22
    van Gils JM, Zwaginga JJ, Hordijk PL. Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 2009; 85: 195204.
  • 23
    Kulkarni S, Dopheide SM, Yap CL, Ravanat C, Freund M, Mangin P, Heel KA, Street A, Harper IS, Lanza F, Jackson SP. A revised model of platelet aggregation. J Clin Invest 2000; 105: 78391.
  • 24
    Maxwell MJ, Westein E, Nesbitt WS, Giuliano S, Dopheide SM, Jackson SP. Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood 2007; 109: 56676.
  • 25
    Savage B, Saldivar E, Ruggeri ZM. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 1996; 84: 28997.
  • 26
    Packham MA, Mustard JF. Platelet adhesion. Prog Hemost Thromb 1984; 7: 21188.
  • 27
    Ruggeri ZM, Orje JN, Habermann R, Federici AB, Reininger AJ. Activation-independent platelet adhesion and aggregation under elevated shear stress. Blood 2006; 108: 190310.
  • 28
    Nachman RL, Leung LL. Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen. J Clin Invest 1982; 69: 2639.
  • 29
    Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC. Structural basis of collagen recognition by integrin alpha2beta1. Cell 2000; 101: 4756.
  • 30
    Ruggeri ZM. Mechanisms initiating platelet thrombus formation. Thromb Haemost 1997; 78: 6116.
  • 31
    Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO, Wagner DD. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest 2000; 106: 38592.
  • 32
    Dubois C, Panicot-Dubois L, Gainor JF, Furie BC, Furie B. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest 2007; 117: 95360.
  • 33
    Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost 2006; 4: 22307.
  • 34
    Corti R, Farkouh ME, Badimon JJ. The vulnerable plaque and acute coronary syndromes. Am J Med 2002; 113: 66880.
  • 35
    Libby P. Inflammation in atherosclerosis. Nature 2002; 420: 86874.
  • 36
    Reininger AJ, Bernlochner I, Penz SM, Ravanat C, Smethurst P, Farndale RW, Gachet C, Brandl R, Siess W. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010; 55: 114758.
  • 37
    Penz SM, Reininger AJ, Toth O, Deckmyn H, Brandl R, Siess W. Glycoprotein Ibα inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. Thromb Haemost 2007; 97: 43543.
  • 38
    Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD. The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci USA 2007; 103: 169005.
  • 39
    Bizzozero J. Über einen neuen Formbestandteil des Blutes und dessen Rolle bei der Thrombose und Blutgerinnung. Virchow's Arch Path Anat Physiol Klin Med 1882; 90: 261332.
  • 40
    Brewer DB. Max Schultze (1865), G. Bizzozero (1882) and the discovery of the platelet. Br J Haematol 2006; 133: 2518.
  • 41
    Mickelson JK, Lakkis NM, Villarreal-Levy G, Hughes BJ, Smith CW. Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease. J Am Coll Cardiol 1996; 28: 34553.
  • 42
    von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 2007; 100: 2740.
  • 43
    Rinder HM, Bonan JL, Rinder CS, Ault KA, Smith BR. Dynamics of leukocyte–platelet adhesion in whole blood. Blood 1991; 78: 17307.
  • 44
    Zhao L, Bath PM, May J, Lösche W, Heptinstall S. P-selectin, tissue factor and CD40 ligand expression on platelet–leucocyte conjugates in the presence of a GPIIb/IIIa antagonist. Platelets 2003; 14: 47380.
  • 45
    Jungi TW, Spycher MO, Nydegger UE, Barandun S. Platelet–leukocyte interaction: selective binding of thrombin-stimulated platelets to human monocytes, polymorphonuclear leukocytes, and related cell lines. Blood 1986; 67: 62936.
  • 46
    Rinder HM, Bonan JL, Rinder CS, Ault KA, Smith BR. Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood 1991; 78: 17609.
  • 47
    Hamburger SA, McEver RP. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood 1990; 75: 5504.
  • 48
    Larsent E, Celi A, Gilbert GE, Furie BC, Erban JK, Bonfanti R, Wagner DD, Furie' B. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 1989; 59: 30512.
  • 49
    Yang J, Furie BC, Furie B. The biology of P-selectin glycoprotein ligand-1: its role as a selectin counterreceptor in leukocyte–endothelial and leukocyte–platelet interaction. Thromb Haemost 1999; 81: 17.
  • 50
    Kappelmayer J, Kiss A, Karaaszi E, Veszpreami A, Jako J, Kiss C. Identification of P-selectin glycoprotein ligand-1 as a useful marker in acute myeloid leukaemias. Br J Haematol 2001; 115: 9039.
  • 51
    Tsuji T, Nagata K, Koike J, Todoroki N, Irimura T. Induction of superoxide anion production from monocytes and neutrophils by activated platelets through the P-selectin-sialyl Lewis X interaction. J Leukoc Biol 1994; 56: 5837.
  • 52
    Hidari KI, Weyrich AS, Zimmerman GA, McEver RP. Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem 1997; 272: 287506.
  • 53
    Urzainqui A, Serrador JM, Viedma F, Yanez-Mo M, Rodriguez A, Corbi AL, Alonso-Lebrero JL, Luque A, Deckert M, Vazquez J, Sanchez-Madrid FITA. M-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity 2002; 17: 40112.
  • 54
    Haller H, Kunzendorf U, Sacherer K, Lindschau C, Walz G, Distler A, Luft FC. T cell adhesion to P-selectin induces tyrosine phosphorylation of pp125 focal adhesion kinase and other substrates. J Immunol 1997; 158: 10617.
  • 55
    Wang HB, Wang JT, Zhang L, Geng ZH, Xu WL, Xu T, Huo Y, Zhu X, Plow EF, Chen M, Geng JG. P-selectin primes leukocyte integrin activation during inflammation. Nat Immunol 2007; 8: 88292.
  • 56
    van Gils JM, Zwaginga JJ, Hordijk PL. Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 2009; 85: 195204.
  • 57
    Heijnen HF, Debili N, Vainchencker W, Breton-Gorius J, Geuze HJ, Sixma JJ. Multivesicular bodies are an intermediate stage in the formation of platelet alpha-granules. Blood 1998; 91: 2313- 25.
  • 58
    Sixma JJ, Slot J-W, Geuze HJ. Immunocytochemical localization of platelet granule proteins. Methods Enzymology 1989; 169: 30111.
  • 59
    Pollard TD, Fujiwara K, Handin R, Weiss G. Contractile proteins in platelet activation and contraction. Ann N Y Acad Sci 1977; 283: 21836.
  • 60
    White JG, Gerrard JM. Interaction of microtubules and microfilaments in platelet contractile physiology. Methods Achiev Exp Pathol 1979; 9: 139.
  • 61
    Loftus JC, Choate J, Albrecht RM. Platelet activation and cytoskeletal reorganization : high voltage electron microscopic examination of intact and Triton-extracted whole mounts. J Cell Biol 1989; 98: 201925.
  • 62
    Reed GL, Fitzgerald ML, Polga J. Molecular mechanisms of platelet exocytosis: insights into the ‘secrete’ life of thrombocytes. Blood 2000; 96: 333442.
  • 63
    Flaumenhaft R. Molecular Basis of Platelet Granule Secretion. Arterioscler Thromb Vasc Biol 2003; 23: 115260.
  • 64
    Ren Q, Ye S, Whiteheart SW. The Platelet Release Reaction: Just when you thought platelet secretion was simple. Curr Opin Hematol 2008; 15: 53741.
  • 65
    Painter RG, Ginsberg MH. Centripetal myosin redistribution in thrombinstimulated platelets: relationship to platelet factor 4 secretion. Exp Cell Res 1984; 155: 198212.
  • 66
    Kirkpatrick JP, McIntire LV, Moake JL, Cimo PL. Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. Thromb Haemost 1980; 42: 14839.
  • 67
    Lefebvre P, White JG, Krumwiede MD, Cohen I. Role of actin in platelet function. Eur J Cell Biol 1993; 62: 194204.
  • 68
    White JG, Rao GH. Effects of a microtubule stabilizing agent on the response of platelets to vincristine. Blood 1982; 60: 47483.
  • 69
    Cox AC. Cytochalasin E enhances the protein kinase C-dependent process of secretion. Biochem Biophys Res Commun 1988; 150: 74551.
  • 70
    Yatomi Y, Higashihara M, Tanabe A, Ohashi T, Takahata K, Kariya T, Kume S. Separable function of platelet release reaction and clot retraction. Biochem Biophys Res Commun 1986; 140: 32934.
  • 71
    Flaumenhaft R, Dilks JR, Rozenvayn N, Monahan-Earley RA, Feng D, Dvorak AM. The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion. Blood 2005; 105: 387987.
  • 72
    Ren Q, Wimmer C, Chicka MC, Ye S, Ren Y, Hughson FM, Whiteheart SW. Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. Blood 2010; 116: 86977.
  • 73
    van Nispen tot Pannerden H, de Haas F, Geerts W, Posthuma G, van Dijk S, Heijnen HFG. The platelet interior revisited: electron tomography reveals tubular alpha granule subtypes. Blood 2010; 116: 114756.
  • 74
    Sehgal S, Storrie B. Evidence that differential packaging of the major platelet granule proteins von Willebrand factor and fibrinogen can support their differential release. J Thromb Haemost 2007; 5: 200916.
  • 75
    Italiano JE, Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet {alpha} granules and differentially released. Blood 2008; 111: 122733.
  • 76
    Maree AO, Fitzgerald DJ. Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation 2007; 115: 2196207.
  • 77
    Rinder CS, Student LA, Bonan JL, Rinder HM, Smith BI. Aspirin does not inhibit adenosine diphosphate-induced platelet a-granule release. Blood 1993; 82: 505- 12.
  • 78
    Li N, Hu H, Hjemdahl P. Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry. Thromb Res 2003; 111: 16570.
  • 79
    Moshfegh K, Redondo M, Julmy F, Wuillemin WA, Gebauer MU, Haeberli A, Meyer BJ. Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy. J Am Coll Cardiol 2000; 36: 699705.
  • 80
    Frelinger AL, Li Y, Linden MD, Barnard MR, Fox ML, Christie DJ, Furman MI, Michelson AD. Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization. Circulation 2009; 120: 258696.
  • 81
    Levine GN, Berger PB, Cohen DJ, Maree AO, Rosenfield K, Wiggins BS, Spinler SA. Newer pharmacotherapy in patients undergoing percutaneous coronary interventions: a guide for pharmacists and other health care professionals. Pharmacotherapy 2006; 26: 153756.
  • 82
    CAPRIE Steering Committee. A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet 1996; 348: 132939.
  • 83
    Sabatine MS, Cannon CP, Gibson CM, Lopez-Sendon JL, Montalescot G, Theroux P, Claeys MJ, Cools F, Hill KA, Skene AM, McCabe CH, Braunwald E. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 2005; 352: 117989.
  • 84
    Sabatine MS, Cannon CP, Gibson CM, Lopez-Sendon JL, Montalescot G, Theroux P, Lewis BS, Murphy SA, McCabe CH, Braunwald E. Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study. JAMA 2005; 294: 122432.
  • 85
    Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matias-Guiu J, Rupprecht HJ, MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 2004; 364: 3317.
  • 86
    Leon C, Alex M, Klocke A, Morgenstern E, Moosbauer C, Eckly A, Spannagl M, Gachet C, Engelmann B. Platelet ADP receptors contribute to the initiation of intravascular coagulation. Blood 2004; 103: 594600.
  • 87
    Farid NA, Payne CD, Small DS, Winters KJ, Ernest CS 2nd, Brandt JT, Darstein CD, Jakubowski JA, Salazar DE. Cytochrome P450 3A inhibition by ketonazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clin Pharmacol Ther 2007; 81: 73541.
  • 88
    Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, Neuman FJ, Ardissino D, De Servi S, Murphy SA, Riesmeyer J, Weerakkody G, Gibson CM, Antman EM, TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 20015.
  • 89
    Van Giezen JJJ, Humphries RG. Preclinical and clinical studies with selective reversible direct P2Y12 antagonists. Sem Thromb Hemost 2005; 31: 195204.
  • 90
    Cattaneo M, Podda GM. State of the art of new P2Y12 antagonists. Intern Emerg Med 2010; 5: 38591.
  • 91
    Storey RF, Judge HM, Wilcox RG, Heptinstall S. Inhibition of ADP-induced P-selectin expression and platelet–leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Thromb Haemost 2002; 88: 48894.
  • 92
    Braun OO, Johnell M, Varenhorst C, James S, Brandt JT, Jakubowski JA, Winters KJ, Wallentin L, Erlinge D, Siegbahn A. Greater reduction of platelet activation markers and platelet–monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease. Thromb Haemost 2008; 100: 62633.
  • 93
    Antonino MJ, Mahla E, Bliden KP, Tantry US, Gurbel PA. Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting. Am J Cardiol 2009; 103: 154650.
  • 94
    Offermanns S. Activation of platelet function through G protein–coupled receptors. Circ Res 2006; 99: 1293304.
  • 95
    Newton AC. Regulation of protein kinase C. Curr Opin Cell Biol 1997; 9: 16167.
  • 96
    Mellor H, Parker PJ. The extended protein kinase C superfamily. Biochem J 1998; 332: 28192.
  • 97
    Paul BZ, Jin J, Kunapuli SP. Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. J Bio Chem 1999; 274: 2910814.
  • 98
    Quinton TM, Kim S, Dangelmaier C, Dorsam RT, Jin J, Daniel JL, Kunapuli SP. Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation. Biochem J 2002; 368: 53553.
  • 99
    Chung SH, Polgar J, Reed GL. Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets. J Biol Chem 2000; 275: 2528691.
  • 100
    Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, Heemskerk JW, Poole AW. PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest 2009; 119: 399407.
  • 101
    Murugappan S, Tuluc F, Dorsam RT, Shankar H, Kunapuli SP. Differential role of protein kinase C delta isoform in agonist-induced dense granule secretion in human platelets. J Biol Chem 2004; 279: 23607.
  • 102
    Gilio K, Harper MT, Cosemans JM, Konopatskaya O, Munnix IC, Prinzen L, Leitges M, Liu Q, Molkentin JD, Heemskerk JW, Poole AW. Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J Biol Chem 2010; 285: 234109.
  • 103
    Li Z, Zhang G, Le Breton GC, Gao X, Malik AB, Du X. Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem 2003; 278: 3072531.
  • 104
    Paul BZ, Jin J, Kunapuli SP. Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. J Biol Chem 1999; 274: 2910814.
  • 105
    Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001; 409: 2027.
  • 106
    Dean WL, Chen D, Brandt PC, Vanaman TC. Regulation of platelet plasmalemma Ca2+-ATPase by cAMP-dependent and tyrosin phosphorylation. J Biol Chem 1997; 272: 151139.
  • 107
    Hallam TJ, Daniel JL, Kendrick Jones J, Rink TJ. Relationship between cytosplasmic free calcium and myosin light chain phosphorylation in intact platelets. Biochem J 1985; 232: 3737.
  • 108
    Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter J. cAMP and cGMP-dependent protein kinase [hosphorylation sites of the focal vasodilator-stimulated phosphoprotein (VASP) in vitro in intact human plateltes. J Biol Chem 1994; 269: 1450917.
  • 109
    Li Z, Zhang G, Marjanovic JA, Ruan C, Du X. A platelet secretion pathway mediated by cGMP-dependent protein kinase. J Biol Chem 2004; 279: 4246975.
  • 110
    Iyú D, Glenn GR, White AE, Fox SC, Heptinstall S. Adenosine derived from ADP can contribute to inhibition of platelet. Arterioscler Thromb Vasc Biol 2010; 31: 41622.
  • 111
    Born GV, Smith JB. Uptake, metabolism and release of (3H)-adrenalin by human platelets. Br J Pharmacol 1970; 39: 76578.
  • 112
    Smith CC. Evidence for separate serotonin and catecholamine compartments in human platelets. Biochim Biophys Acta 1996; 1291: 14.
  • 113
    Kaywin P, McDonough M, Insel PA, Shattil SJ. Platelet function is essential in thrmbocythemia: decreased epinephrine responsiveness of platelets associated with a deficiency in alpha-adrenergic receptors. N Engl J Med 1978; 299: 5059.
  • 114
    Woulfe D, Jiang H, Mortensen R, Yang J, Brass LF. Activation of Rap1B by Gi family members in platelets. J Biol Chem 2002; 277: 2338290.
  • 115
    Hjemdahl P, Chronos NA, Wilson DJ, Bouloux P, Goodall AH. Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression. Arterioscler Thromb Vasc Biol 1994; 14: 7784.
  • 116
    Horn NA, Anastase DM, Hecker KE, Baumert JH, Robitzsch T, Rossaint R. Epinephrine enhances platelet–neutrophil adhesion in whole blood in vitro. Anesth Analg 2005; 100: 5206.
  • 117
    Iyú D, Glenn JR, White AE, Johnson AJ, Fox SC, Heptinstall S. The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. Platelets 2010; 21: 32942.
  • 118
    Fabre JE, Nguyen M, Athirakul K, Coggins K, McNeish JD, Austin JD, Austin S, Parisse LK, FitzGerald GA, Coffman TM, Koller BH. Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. J Clin Invest 2001; 107: 60310.
  • 119
    Ma H, Hara A, Xiao CY, Okada Y, Takahata O, Nakaya K, Sugimoto Y, Ichikawa A, Narumiya S, Ushikubi F. Increased bleeding tendency and decrease susceptibility to thromboembolism in mice lacking the prostaglandin E2 receptor subtype EP(3). Circulation 2001; 104: 117680.
  • 120
    Iyú D, Jüttner M, Glenn JR, White AE, Johnson AJ, Fox SC, Heptinstall S. PGE(1) and PGE(2) modify platelet function through different prostanoid receptors. Prostaglandins Other Lipid Mediat 2010. [Epub ahead of print].
  • 121
    Queen LR, Xu B, Horinouchi K, Fisher I, Ferro A. B2-adrenoreceptors activate nitric oxide synthase in human platelets. Circ Res 2000; 87: 3944.
  • 122
    Morell AN, Matsushita K, Chiles K, Scharp RB, Yamakuchi M, Mason RJA, Bergmeier W, Mankowski JL, Baldwin W, Farady N, Lowenstein CJ. Regulation of platelet granule exocytosis by S-nitrosylation. Proc N Acad Sci 2005; 102: 37827.
  • 123
    Goubareva I, Gkaliagkousi E, Shah A, Queen L, Ferro A. Age decreases nitric oxide synthesis and responsiveness in human platelets and increases formation of monocyte–platelet aggregates. Cardiovasc Res 2007; 75: 793802.
  • 124
    Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofman F, Du X. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 2003; 112: 7786.
  • 125
    Li Z, Ajdic J, Eigenthaler M, Du X. A predominant role for cAMP-dependent protein kinase in cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood 2003; 101: 44239.
  • 126
    Kariyazono H, Nakamra K, Shinkawa T, Yamaguchi T, Sakata R, Yamada K. Inhibition of platelet aggregation and the release of P-selectin from platelets by cilostazol. Thrombosis Res 2001; 101: 44553.
  • 127
    Ito H, Miyakoda G, Mori T. Cilostazol inhibits platelet leukocyte interaction by suppression of platelet activation. Platelets 2004; 15: 293301.
  • 128
    Lee SW, Park SW, Kim YH. Comparison of triple versus dual anti-platelet therapy after drug-eluting stent implantation (from the DECLARE-Long trial). Am J Cardiol 2007; 100: 11038.
  • 129
    Serebruany VL, Glassman AH, Malinin AI, Atar D, Sane DC, Oshrine BR, Ferguson JJ, O'Connor CM. Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin. Eur J Heart Fail 2003; 5: 51721.
  • 130
    Morel-Kopp MC, McLean L, Chen Q, Tofler GH, Tennant C, Maddison V, Ward CM. The association of depression with platelet activation: evidence for a treatment effect. J Thromb Haemos 2009; 7: 57381.
  • 131
    Duman RS. Novel therapeutic approaches beyond the serotonin receptor. Biol Psychiatry 1998; 44: 32435.
  • 132
    Xu Q, Yi LT, Pan Y, Wang X, Li YC, Li JM, Wang CP, Kong LD. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 71525.
  • 133
    Li YC, Wang FM, Pan Y, Qiang LQ, Cheng G, Zhang WY, Kong LD. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 4354.
  • 134
    Bosch X, Marrugat J, Sanchis J. Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes. Cochrane Database Syst Rev 2010; (9): CD002130.
  • 135
    O'Neill WW, Serruys P, Knudtson M, van Es GA, Timmis GC, van der Zwaan C, Kleiman J, Gong J, Roecker EB, Dreiling R, Alexander J, Anders R. Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization. EXCITE Trial Investigators. Evaluation of Oral Xemilofiban in Controlling Thrombotic Events. N Engl J Med 2000; 342: 131624.
  • 136
    Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: a randomised trial. The SYMPHONY Investigators. Sibrafiban versus Aspirin to Yield Maximum Protection from Ischemic Heart Events Post-acute Coronary Syndromes. Lancet 2000; 355: 33745.
  • 137
    SYMPHONY II Investigators. Randomized trial of aspirin, sibrafiban, or both for secondary prevention after acute coronary syndromes. Circulation 2001; 103: 172733.
  • 138
    Grüner S, Prostredna M, Koch M, Miura Y, Schulte V, Jung SM, Moroi M, Nieswandt B. Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice. Blood 2005; 105: 14929.
  • 139
    Schulte V, Rabie T, Prostredna M, Aktas B, Gruner S, Nieswandt B. Targeting of the collagen-binding site on glycoprotein VI is not essential for in vivo depletion of the receptor. Blood 2003; 101: 394852.
  • 140
    Smethurst PA, Joutsi-Korhonen L, O'Connor MN, Wilson E, Jennings NS, Garner SF, Zhang Y, Knight CG, Dafforn TR, Buckle A. IJsseldijk MJ, De Groot PG, Watkins NA, Farndale RW, Ouwehand WH. Identification of the primary collagen binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. Blood 2004; 103: 90311.
  • 141
    Matsumoto Y, Takizawa H, Gong X, Le S, Lockyer S, Okuyama K, Tanaka M, Yoshitake M, Tandon NN, Kambayashi J. Highly potent anti-human GPVI monoclonal antibodies derived from GPVI knockout mouse immunization. Thromb Res 2007; 119: 31929.
  • 142
    Kato-Takagaki K, Mizukoshi Y, Yoshizawa Y, Akazawa D, Torii Y, Ono K, Tanimura R, Shimada I, Takahashi H. Structural and interaction analysis of glycoprotein VI-binding peptide selected from a phage display library. J Biol Chem 2009; 284: 1072027.
  • 143
    Keefe AD, Shaub RG. Aptamers as candidate therapeutics for cardiovascular indications. Curr Opin Pharm 2008; 8: 14752.
  • 144
    McGhie AI, McNatt J, Ezov N, Cui K, Lowell K, Mower LK, Hagay Y, Buja LM, Garfinkel LI, Gorecki M, Willerson JT. Abolition of cyclic flow variations in stenosed, endothelium-injured coronary arteries in nonhuman primates with a peptide fragment (VCL) derived from human plasma von Willebrand factor–glycoprotein Ib binding domain. Circulation 1994; 90: 297681.
  • 145
    Diener JL, Daniel Lagassé HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost 2009; 7: 115562.
  • 146
    Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, Horvath CJ, Merlino PG, Marsh HN, Healy JM, Boufakhreddine S, Holohan TV, Schaub RG. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation 2007; 116: 267886.
  • 147
    Wang L, Brown JR, Varki A, Esko JD. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest 2002; 110: 12736.
  • 148
    Oostingh GJ, Pozgajova M, Ludwig RJ, Krahn T, Boehncke WH, Nieswandt B, Schön MP. Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions. Haematologica 2007; 92: 50212.
  • 149
    Skurk C, Buerke M, Guo JP, Paulson J, Lefer AM. Sialyl Lewisx-containing oligosaccharide exerts beneficial effects in murine traumatic shock. Am J Physiol Heart Circ Physiol 1994; 267: H212431.
  • 150
    Sanders WJ, Gordon EJ, Dwir O, Beck PJ, Alon R, Kiessling LL. Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics. J Biol Chem 1999; 274: 52718.
  • 151
    Hayward R, Campbell B, Shin YK, Scalia R, Lefer AM. Recombinant soluble P-selectin glycoprotein ligand-1 protects against myocardial ischemic reperfusion injury in cats. Cardiovasc Res 1999; 41: 6576.
  • 152
    Jenison RD, Jennings SD, Walker DW, Bargatze RF, Parma D. Oligonucleotide inhibitors of P-selectin-dependent neutrophil–platelet adhesion. Antisense Nucleic Acid Drug Dev 1998; 8: 26579.