Current progress in pharmacogenetics


Dr John D. Blakey PhD, Respiratory Biomedical Research Unit, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, UK.
Tel.: +44 (0)115 8232768
Fax: +44 (0)115 8231946
Prof. Ian P. Hall MD, Division of Therapeutics and Molecular Medicine, South Block, Queen's Medical Centre, Nottingham NG7 2UH, UK.
Tel.: +44 (0)115 8231064
Fax: +44 (0)115 8231059


The study of genetic variation has the potential to aid understanding of the mechanisms underlying the observed inter-individual variation in drug response and by which idiosyncratic adverse effects occur. In this review, we outline current progress in pharmacogenetics using examples to highlight both mechanisms of influence of polymorphisms and research strategies for their detection. In the final sections we discuss contemporary challenges for both researchers and clinicians.