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Figure S1 (A) Correlation of renal clearance of unconjugated rotigotine with creatinine clearance; (•) individual estimations, (—) result of linear regression. (B) Correlation of rate constant of unconjugated rotigotine elimination with creatinine clearance; (•) individual estimations, (—) result of linear regression

Figure S2 (A) Correlation of renal clearance of conjugated rotigotine with creatinine clearance; (•) individual estimations, (—) result of linear regression. (B) Correlation of rate constant of conjugated rotigotine elimination with creatinine clearance; (•) individual estimations, (—) result of linear regression

Table S1 Statistical comparison of Cmax and AUC(0,tlast) between patient groups with different stages of renal insufficiency and healthy subjects (point estimates [least squares means] and 90% confidence interval)

Table S2 Pharmacokinetic parameters of total N-desalkyl metabolites of rotigotine

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