Pre-hypertension: how low to go and do drugs have a role?
Article first published online: 6 JAN 2012
© 2011 The Author. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society
British Journal of Clinical Pharmacology
Volume 73, Issue 2, pages 187–193, February 2012
How to Cite
McInnes, G. (2012), Pre-hypertension: how low to go and do drugs have a role?. British Journal of Clinical Pharmacology, 73: 187–193. doi: 10.1111/j.1365-2125.2011.04092.x
- Issue published online: 6 JAN 2012
- Article first published online: 6 JAN 2012
- Accepted manuscript online: 26 AUG 2011 05:14PM EST
- Received; 18 March 2011; Accepted; 16 August 2011; Accepted Article; 26 August 2011
- antihypertensive drugs;
- blood pressure;
People with pre-hypertension (high blood pressure but below the conventional threshold for intervention with antihypertensive drugs) undoubtedly have increased risk of cardiovascular and other complications. However, the vast majority has low absolute risk and whether treatment would be beneficial is uncertain. While pharmacotherapy has attractions from a public health perspective, clinicians and crucially those with pre-hypertension require robust evidence that drug treatment will lead to short term as well as long term gains. Any changes in recommendations should await adequately powered outcome studies which provide solid evidence of the magnitude of absolute risk reduction in treating pre-hypertension and assessment of the cost-effectiveness.