Insulin at normal physiological levels does not prolong QTc interval in thorough QT studies performed in healthy volunteers
Version of Record online: 10 JAN 2013
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society
British Journal of Clinical Pharmacology
Volume 75, Issue 2, pages 392–403, February 2013
How to Cite
Taubel, J., Lorch, U., Ferber, G., Singh, J., Batchvarov, V. N., Savelieva, I. and Camm, A. J. (2013), Insulin at normal physiological levels does not prolong QTc interval in thorough QT studies performed in healthy volunteers. British Journal of Clinical Pharmacology, 75: 392–403. doi: 10.1111/j.1365-2125.2012.04376.x
- Issue online: 10 JAN 2013
- Version of Record online: 10 JAN 2013
- Accepted manuscript online: 10 JUL 2012 05:44AM EST
- Manuscript Accepted: 18 JUN 2012
- Manuscript Received: 9 FEB 2012
- 8Shortening of the QT interval after food can be used to demonstrate assay sensitivity in thorough QT studies. J Clin Pharmacol 2011 [Epub ahead of print]., , , , .
- 13R Development Core Team. 2011). R: a language and environment for statistical computing [online]. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, Available at http://www.R-project.org/ (last accessed May 2012).
- 14ICH Harmonized Tripartite Guideline E14. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs. International Conference on Harmonization, Step 4, Guideline, EMEA, CHMP/ICH/2/04, 2005.
- 19ICH Harmonized Tripartite Guideline E14. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs. International conference on harmonisation, E14 Implementation and working group, Question and Answers, 2008.